Unstable angina - a definitive role for statins in secondary prevention

Colquhoun, D. (2000) Unstable angina - a definitive role for statins in secondary prevention. International Journal of Clinical Practice, 54 6: 383-389.

Author Colquhoun, D.
Title Unstable angina - a definitive role for statins in secondary prevention
Journal name International Journal of Clinical Practice   Check publisher's open access policy
ISSN 1368-5031
Publication date 2000-01-01
Sub-type Critical review of research, literature review, critical commentary
Volume 54
Issue 6
Start page 383
End page 389
Total pages 7
Place of publication Surrey, England
Publisher Medicom International
Language eng
Subject C3
321003 Cardiology (incl. Cardiovascular Diseases)
730106 Cardiovascular system and diseases
Abstract Unstable angina is a life-threatening disease. The overall incidence is estimated to be between 0.1 and 0.2% and, of those admitted to hospital, up to 5% die within the first six weeks. With such a high prevalence and poor prognosis, there is still a clear need for improved secondary preventive treatment. Several landmark statin trials (CARE, LIPID and 4-S) have now shown the benefits of lowering cholesterol, starting months after an acute coronary event, and several smaller studies (such as L-CAD, PTT and RECIFE) have demonstrated the clinical benefits of very early statin treatment. Recent research suggests the underlying cause of the disease, atherosclerosis, is a dynamic and potentially reversible process. Statins may tip this balance in favour of resolution by cholesterol lowering and through pleiotropic effects independent of lipid lowering. Pravastatin, when given very early in the clinical course: has already been shown to improve both plaque stability and endothelial function, as well as clinical outcome, suggesting it as the drug of choice in early secondary prevention.
Keyword Medicine, General & Internal
Acute Myocardial-infarction
Smooth-muscle Cells
Coa Reductase Inhibitors
Acute Coronary Syndromes
Cholesterol-lowering Therapy
Artery Disease
Heart-disease
Atherosclerotic Plaques
Endothelial Dysfunction
Pravastatin Sodium
Q-Index Code C3

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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Created: Tue, 10 Jun 2008, 23:12:13 EST