Cloning and characterisation of the Sry-related transcription factor gene Sox8

Schepers, Goslik E., Bullejos, Monica, Hosking, Brett M. and Koopman, Peter (2000) Cloning and characterisation of the Sry-related transcription factor gene Sox8. Nucleic Acids Research, 28 6: 1473-1480. doi:10.1093/nar/28.6.1473


Author Schepers, Goslik E.
Bullejos, Monica
Hosking, Brett M.
Koopman, Peter
Title Cloning and characterisation of the Sry-related transcription factor gene Sox8
Journal name Nucleic Acids Research   Check publisher's open access policy
ISSN 0305-1048
1362-4962
Publication date 2000-03-01
Year available 2000
Sub-type Article (original research)
DOI 10.1093/nar/28.6.1473
Open Access Status DOI
Volume 28
Issue 6
Start page 1473
End page 1480
Total pages 8
Place of publication Oxford
Publisher Oxford University Press
Language eng
Subject C1
270205 Genetic Development (incl. Sex Determination)
780105 Biological sciences
Abstract SOX proteins form a large family of transcription factors related by a DNA-binding domain known as the HMG box. Some 30 Sox genes have been identified in mammals and orthologues have been found in a wide range of other metazoans, Sox genes are highly conserved and are known to play important roles in embryonic development, including roles in gonadal, central nervous system, neural crest and skeletal development, Several SOX genes have been implicated in human congenital diseases. We report here the isolation of Sox8 and its characterisation in mice and humans, This gene has a remarkably similar primary structure and genomic organisation to the campomelic dysplasia gene SOX9 and the Waardenburg-Shah syndrome gene SOX10, SOX8 protein is able to bind to canonical SOX target DNA sequences and activate transcription in vitro through two separate trans-activation regions. Further, Sox8 is expressed in the central nervous system, limbs, kidneys, gonads and craniofacial structures during mouse embryo development, Sox8 maps to the t complex on mouse chromosome 17 and to human chromosome 16p13.3, a region associated with the microphthalmia-cataract syndrome CATM and the alpha-thalassemia/mental retardation syndrome ATR-16.
Keyword Biochemistry & Molecular Biology
Autosomal Sex Reversal
Central-nervous-system
Box-containing Gene
Activates Transcription
Embryonic-development
Campomelic Dysplasia
Determining Region
Collagen Gene
Ii Collagen
Mouse
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Tue, 10 Jun 2008, 23:11:08 EST