Origins and functions of phagocytes in the embryo

Lichanska, A. M. and Hume, D. A. (2000) Origins and functions of phagocytes in the embryo. Experimental Hematology, 28 6: 601-611. doi:10.1016/S0301-472X(00)00157-0

Author Lichanska, A. M.
Hume, D. A.
Title Origins and functions of phagocytes in the embryo
Journal name Experimental Hematology   Check publisher's open access policy
ISSN 0301-472X
Publication date 2000-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S0301-472X(00)00157-0
Open Access Status DOI
Volume 28
Issue 6
Start page 601
End page 611
Total pages 11
Place of publication New York
Publisher Elsevier
Language eng
Subject C1
270100 Biochemistry and Cell Biology
780105 Biological sciences
Abstract Objective. To review the data on the origins, phenotype, and function of embryonic phagocytes that has accumulated over past decade. Data Sources. Most of the relevant articles were selected based on the PubMed database entries. In additional, the Interactive Fly database ( 1aahome.htm), FlyBase (, and TBase ( were used to search for relevant information and articles. Data Synthesis. Phagocytes in a vertebrate embryo develop in two sites (yolk sac and liver) and contribute to organogenesis in part through their ability to recognize and clear apoptotic cells. Yolk sac-derived phagocytes differ in differentiation pathway and marker gene expression from macrophages produced via classic hematopoietic progenitors in the liver. Conclusion, We argue that yolk sac-derived phagocytes constitute a separate cell lineage. This conclusion raises the question of whether primitive phagocytes persist into the adulthood. (C) 2000 International Society for Experimental Hematology. Published by Elsevier Science Inc.
Keyword Hematology
Medicine, Research & Experimental
Yolk Sac
Colony-stimulating Factor
Programmed Cell-death
Macrophage Scavenger Receptors
Transcription Factor Pu.1
Hematopoietic Stem-cells
Endothelial Growth-factor
Osteopetrotic Op/op Mice
Alpha-deficient Mice
Fetal Mouse-liver
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 86 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 10 Jun 2008, 22:59:09 EST