Platinum pharmacokinetics in sulphur-crested cockatoos (Cacatua galerita) following single-dose cisplatin infusion

Filippich, L. J., Bucher, A. M. and Charles, B. G. (2000) Platinum pharmacokinetics in sulphur-crested cockatoos (Cacatua galerita) following single-dose cisplatin infusion. Australian Veterinary Journal, 78 6: 406-411. doi:10.1111/j.1751-0813.2000.tb11829.x


Author Filippich, L. J.
Bucher, A. M.
Charles, B. G.
Title Platinum pharmacokinetics in sulphur-crested cockatoos (Cacatua galerita) following single-dose cisplatin infusion
Journal name Australian Veterinary Journal   Check publisher's open access policy
ISSN 0005-0423
Publication date 2000-01-01
Sub-type Article (original research)
DOI 10.1111/j.1751-0813.2000.tb11829.x
Volume 78
Issue 6
Start page 406
End page 411
Total pages 6
Place of publication Melbourne
Publisher Aust Vet. Assoc.
Language eng
Subject C1
300501 Veterinary Medicine
780105 Biological sciences
Abstract Objective To determine the pharmacokinetics of platinum (Pt) in cockatoos. Design A pharmacokinetic study of Pt, following a single IV infusion of cisplatin, was done in six healthy sulphur-crested cockatoos (Cacatua galerita). Procedure Birds were hydrated for 1 h before and 2 h after a 1-h cisplatin infusion (1 mg/kg, IV). Serial blood samples were collected for 96 h after initiation of the infusion and urine was collected for 2 h during the hydration period after cisplatin administration. Tissue samples from 10 organs were obtained at necropsy, 96 h after cisplatin infusion. Total Pt and filterable Pt in plasma, urinary Pt and tissue Pt concentrations were assayed by inductively coupled plasma-mass spectrometry. A noncompartmental pharmacokinetic analysis was performed on the plasma and urine data. Results For total Pt and filterable Pt, the respective mean systemic clearances were 0.373 and 0.699 L/kg hourly, the steady stale volumes of distribution were 4.19 and 0.356 L/kg, and the mean residence times were 111 and 0.512 h. Total plasma Pt displayed a bi-exponential decay profile with average half-lives of 0.398 and 79.0 h, while filterable Pt had a monoexponential decay with mean half-life of 0.413 h. The renal clearance during the 2-h postinfusion period was 0.167 L/kg hourly. The kidneys had the highest Pt accumulation (4.54 mu g/g DM). Conclusions and Clinical Relevance Cisplatin infusion in cockatoos was well tolerated and PI plasma concentrations were similar to those measured during treatment of solid tumours in human patients. Despite anatomical, physiological and biochemical differences among animal species, the pharmacokinetic disposition of Pt in the cockatoo shares some features with the kinetics reported previously in rodents, dogs and human beings.
Keyword Veterinary Sciences
Platinum
Pharmacokinetics
Cockatoo
Hydrolysis Products
Intact Cisplatin
Kinetics
Dogs
Cis-dichlorodiammineplatinum(ii)
Chemotherapy
Disposition
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Veterinary Science Publications
 
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Created: Tue, 10 Jun 2008, 22:49:29 EST