No support for linkage to the bipolar regions on chromosomes 4p, 18p, or 18q in 43 schizophrenia pedigrees

Nancarrow, Derek J., Levinson, Douglas F., Taylor, Jennifer M., Hayward, Nicholas K., Walters, Marilyn K., Lennon, David P., Nertney, Deborah A., Jones, Helen L., Mahtani, Melanie M., Kirby, Andrew, Kruglyak, Leonid, Brown, Donna M., Crowe, Raymond R., Andreasen, Nancy C., Black, Donald W., Silverman, Jeremy M., Mohs, Richard C., Siever, Larry J., Endicott, Jean, Sharpe, Lawrence and Mowry, Bryan J. (2000) No support for linkage to the bipolar regions on chromosomes 4p, 18p, or 18q in 43 schizophrenia pedigrees. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 96 2: 224-227. doi:10.1002/(SICI)1096-8628(20000403)96:2<224::AID-AJMG19>3.0.CO;2-2


Author Nancarrow, Derek J.
Levinson, Douglas F.
Taylor, Jennifer M.
Hayward, Nicholas K.
Walters, Marilyn K.
Lennon, David P.
Nertney, Deborah A.
Jones, Helen L.
Mahtani, Melanie M.
Kirby, Andrew
Kruglyak, Leonid
Brown, Donna M.
Crowe, Raymond R.
Andreasen, Nancy C.
Black, Donald W.
Silverman, Jeremy M.
Mohs, Richard C.
Siever, Larry J.
Endicott, Jean
Sharpe, Lawrence
Mowry, Bryan J.
Title No support for linkage to the bipolar regions on chromosomes 4p, 18p, or 18q in 43 schizophrenia pedigrees
Journal name American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics   Check publisher's open access policy
ISSN 1552-4841
1552-485X
Publication date 2000-04-03
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1002/(SICI)1096-8628(20000403)96:2<224::AID-AJMG19>3.0.CO;2-2
Volume 96
Issue 2
Start page 224
End page 227
Total pages 4
Place of publication New York, NY, U.S.A.
Publisher Wiley-Liss
Language eng
Subject C1
1117 Public Health and Health Services
1103 Clinical Sciences
Formatted abstract
These data provide no support for the hypothesis that a schizophrenia susceptibility gene of major to moderate effect within our data set maps to one of these bipolar susceptibility regions on 4p, 18p, and 18q. When our results are considered in the context of those from other researchers, two explanations arise: either the initially positive scores within these regions are the result of type one linkage errors (false positive scores); or a gene(s) of small effect for BPAD, schizophrenia, or both, maps to one or more of these regions. Given issues of power and population stratification in individual data sets, identifying such genes of small effect remains a challenge for the field.
© 2000 Wiley-Liss, Inc.
Q-Index Code C1
Additional Notes Published under "Letter to the Editor"

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collection: School of Medicine Publications
 
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Created: Tue, 10 Jun 2008, 21:38:19 EST