Natural pathogens of laboratory animals and their effects on research

Connole, M. D., Yamaguchi, H., Elad, D., Hasegawa, A., Segal, E. and Torres-Rodriguez, J. M. (2000) Natural pathogens of laboratory animals and their effects on research. Medical Mycology, 38 Supp. 1: 59-65. doi:10.1080/mmy.38.s1.59.65


Author Connole, M. D.
Yamaguchi, H.
Elad, D.
Hasegawa, A.
Segal, E.
Torres-Rodriguez, J. M.
Title Natural pathogens of laboratory animals and their effects on research
Journal name Medical Mycology   Check publisher's open access policy
ISSN 1369-3786
Publication date 2000-01-01
Sub-type Article (original research)
DOI 10.1080/mmy.38.s1.59.65
Open Access Status Not Open Access
Volume 38
Issue Supp. 1
Start page 59
End page 65
Total pages 7
Place of publication Oxford, England
Publisher Bios Scientific Publication
Language eng
Subject C1
270305 Mycology
730101 Infectious diseases
Abstract The natural fungal pathogens of laboratory animals such as rabbits and guinea pigs are mainly dermatophyte species, most commonly Trichophyton mentagrophytes and also, less frequently Microsporum gypseum and M. canis. However, the incidences of infection and clinical disease are low in well-managed animal facilities. Young or immunocompromised rabbits are thought to be most susceptible. Dermatophytes infect the epidermis and adnexal structures, including hair follicles and shafts, usually on or around the head, and cause pruritis, patchy alopecia, erythema and crusting. Histopathological changes in the underlying skin occur and these changes could confound histological studies involving the skin. Yeast infections usually due to Candida spp. have been reported occasionally in laboratory animals. In this paper, the role of rodents in the evaluation of topical antifungal agents, dermatophytosis and two species of Candida, which are natural pathogens of laboratory animals, are discussed in relation to their effects on research. Pneumocystis carinii, an inhabitant of the respiratory tract of laboratory mice and rats, is a pathogen only under conditions of induced or inherent immunodeficiency. Infected mice and rats are likely to develop severe pneumocystosis following immunosuppression and will be rendered unsuitable for most experimental purposes.
Keyword Mycology
Veterinary Sciences
Dermatophytes
Laboratory Animals
Natural Pathogens
Yeast Infections
Experimental Tinea-pedis
Candida-albicans
Adhesion
Mice
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Veterinary Science Publications
 
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Created: Tue, 10 Jun 2008, 21:37:33 EST