Opposite effects of short and continuous oestradiol replacement on CNS responses to hypoxic stress

Buller, K. M. and Day, T. A. (2000) Opposite effects of short and continuous oestradiol replacement on CNS responses to hypoxic stress. Neuroreport, 11 10: 2243-2246. doi:10.1097/00001756-200007140-00036


Author Buller, K. M.
Day, T. A.
Title Opposite effects of short and continuous oestradiol replacement on CNS responses to hypoxic stress
Journal name Neuroreport   Check publisher's open access policy
ISSN 0959-4965
Publication date 2000-07-14
Sub-type Article (original research)
DOI 10.1097/00001756-200007140-00036
Open Access Status
Volume 11
Issue 10
Start page 2243
End page 2246
Total pages 4
Editor David Ottoson
C. Blakemore
W.A. Harris
M.Ito
M. Mishkin
Place of publication London, England
Publisher Lippincott Williams & Wilkins
Language eng
Subject C1
320702 Central Nervous System
730104 Nervous system and disorders
Abstract Oestrogen can alter neuroendocrine responses to stress but the evidence is conflicting. We examined the effects of a shortterm 17 beta-oestradiol surge versus a continuous 17 beta-oestradiol replacement regime on neuroendocrine cell responses to hypoxia in the ovariectomized rat. Short-term oestradiol replacement significantly increased the number of Fos-positive SON and PVN OT cells and VLM Al and CI cells following hypoxia. In contrast, continuous oestradiol replacement significantly decreased the number of hypoxia-induced Fos-positive mPVN, PVN OT and VLM Al and CI and NTS C2 cells. We propose that the effects of oestradiol replacement on stress-induced neuroendocrine responses may be dependent on whether oestrogen levels are rising rapidly or remaining constant over a relatively long period. NeuroReport 11:2243-2246 (C) 2000 Lippincott Williams & Wilkins.
Keyword Neurosciences
Brainstem Catecholamine Cells
C-fos
Hypoxia
Nucleus Tractus Solitarius
Oestrogen
Oxytocin Cells
Paraventricular Nucleus
Supraoptic Nucleus
Ventrolateral Medulla
Pituitary-adrenal Axis
Messenger-ribonucleic-acid
Estrous-cycle
Psychological Stress
Gene-expression
Female Rat
Oxytocin
Neurons
Vasopressin
Receptor
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Physical Sciences Publications
 
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Created: Tue, 10 Jun 2008, 21:32:26 EST