Sodium cromoglycate on plasma protein exudation to topically-applied substance P in the tracheal airways of rats or guinea-pigs in vivo

O'Donnell, Stella Rayner, Coulson, F. R. and Bigg, C. S. (2000) Sodium cromoglycate on plasma protein exudation to topically-applied substance P in the tracheal airways of rats or guinea-pigs in vivo. Pulmonary Pharmacology & Theraputics, 13 1: 43-52. doi:10.1006/pupt.2000.0323


Author O'Donnell, Stella Rayner
Coulson, F. R.
Bigg, C. S.
Title Sodium cromoglycate on plasma protein exudation to topically-applied substance P in the tracheal airways of rats or guinea-pigs in vivo
Journal name Pulmonary Pharmacology & Theraputics   Check publisher's open access policy
ISSN 1094-5539
1522-9629
Publication date 2000-02-01
Sub-type Article (original research)
DOI 10.1006/pupt.2000.0323
Open Access Status
Volume 13
Issue 1
Start page 43
End page 52
Total pages 10
Place of publication New York, NY, U.S.A.
Publisher Academic Press
Language eng
Subject C1
730110 Respiratory system and diseases (incl. asthma)
320500 Pharmacology and Pharmaceutical Sciences
Formatted abstract
Sodium cromoglycate (SCG) was examined against substance P(SP)-induced plasma protein exudation in the trachea of anaesthetized rats and guinea-pigs in vivo to determine whether SCG is a tachykinin receptor antagonist in the airways. A segment of trachea was prepared in situ for continuous perfusion with normal saline. Plasma-derived protein in the perfusion fluid (airway lumen) was increased after topical application of SP (1 μM, 5 min contact). In rats, the SP response was not attenuated by iv SCG but was inhibited (29%) by topical SCG under certain experimental conditions and using a high concentration of SCG (500 μM, 5 min contact, 30 min before SP and with SP). The NK1 receptor antagonist, RP 67 580 (67 μM) abolished the SP response in rats. Sodium cromoglycate did not inhibit the SP response in guinea-pigs (same protocol as in rats). Thus, SCG attenuates plasma protein exudation land presumably microvascular leak) induced by SP in rat tracheal airways but, if SCG is a tachykinin receptor (NK,) antagonist, it not only lacks potency but is species-selective, i.e. more effective in rats than in guinea-pigs.
© 2000 Academic Press.
Keyword Pharmacology & Pharmacy
Respiratory System
Sodium Cromoglycate
Tachykinin Antagonist
Trachea
Rats And Guinea-pigs
Plasma Protein Exudation
Disodium-cromoglycate
Extravasation
Leakage
Asthma
Inflammation
Release
Invitro
Mucosa
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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Created: Tue, 10 Jun 2008, 21:32:03 EST