The symptoms of chronic fatigue syndrome are related to abnormal ion channel function

Chaudhuri, A., Watson, W. S., Pearn, J. and Behan, P. O. (2000) The symptoms of chronic fatigue syndrome are related to abnormal ion channel function. Medical Hypotheses, 54 1: 59-63. doi:10.1054/mehy.1998.0822

Author Chaudhuri, A.
Watson, W. S.
Pearn, J.
Behan, P. O.
Title The symptoms of chronic fatigue syndrome are related to abnormal ion channel function
Journal name Medical Hypotheses   Check publisher's open access policy
ISSN 0306-9877
Publication date 2000-01-01
Sub-type Article (original research)
DOI 10.1054/mehy.1998.0822
Volume 54
Issue 1
Start page 59
End page 63
Total pages 5
Editor David F. Horrobin
Place of publication London
Publisher Harcourt Brace and Company Ltd
Language eng
Subject C1
321021 Psychiatry
730219 Behaviour and health
Abstract The pathogenesis of chronic fatigue syndrome (CFS) is unknown but one of the most characteristic features of the illness is fluctuation in symptoms which can be induced by physical and/or mental stress. Other conditions in which fluctuating fatigue occurs are caused by abnormal ion channels in the cell membrane. These include genetically determined channelopathies, e.g. hypokalemic periodic paralysis, episodic ataxia type 2 and acquired conditions such as neuromyotonia, myasthenic syndromes, multiple sclerosis and inflammatory demyelinating polyneuropathies. Our hypothesis is that abnormal ion channel function underlies the symptoms of CFS and this is supported also by the finding of abnormal cardiac-thallium(201) SPECT scans in CFS, similar to that found in syndrome X, another disorder of ion channels. CFS and syndrome X can have identical clinical symptoms. CFS may begin after exposure to specific toxins which are known to produce abnormal sodium ion channels. Finally, in CFS, increased resting energy expenditure (REE) occurs, a state influenced by transmembrane ion transport. The hypothesis that ion channels are abnormal in CFS may help to explain the fluctuating fatigue and other symptoms. (C) 2000 Harcourt Publishers Ltd.
Keyword Medicine, Research & Experimental
Familial Hemiplegic Migraine
Calcium Channels
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Tue, 10 Jun 2008, 20:54:10 EST