Mucin core protein expression in colorectal cancers with high levels of microsatellite instability indicates a novel pathway of morphogenesis

Biemer-Huttmann, A. E., Walsh, M. D., McGuckin, M. A., Simms, L. A., Young, J., Leggett, B. A. and Jass, J. R. (2000) Mucin core protein expression in colorectal cancers with high levels of microsatellite instability indicates a novel pathway of morphogenesis. Clinical Cancer Research, 6 5: 1909-1916.

Author Biemer-Huttmann, A. E.
Walsh, M. D.
McGuckin, M. A.
Simms, L. A.
Young, J.
Leggett, B. A.
Jass, J. R.
Title Mucin core protein expression in colorectal cancers with high levels of microsatellite instability indicates a novel pathway of morphogenesis
Journal name Clinical Cancer Research   Check publisher's open access policy
ISSN 1078-0432
Publication date 2000-01-01
Year available 2000
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 6
Issue 5
Start page 1909
End page 1916
Total pages 8
Place of publication Philadelphia
Publisher American Association for Cancer Research
Language eng
Subject C1
321020 Pathology
730108 Cancer and related disorders
Abstract Particular mucinous phenotypes have been associated with serrated epithelial polyps of the colon. These polyps also show a high frequency of DNA instability. The aim of this study was to examine the expression of mucins in colorectal cancers that arise through the suppressor and mutator pathways, The immunohistochemical distribution of the human apomucins MUC1, MUC2, MUC4, and MUC5AC was determined in 93 sporadic colorectal cancers classified previously (J, R, Jass st al,, J, Clin, Pathol,, 52: 455-460, 1999) according to levels of DNA microsatellite instability (MSI-H) as 22 MSI-high (MSI-H), 23 MSI-low (MSI-L), and 47 MS stable (MSS), MUC2 expression was observed in 19 (86%) MSI-H, 10 (42%) MSI-L, and 15 (32%) MSS cancers (P = 0.0001); and MUC5AC expression was observed in 17 (77%) MSI-H, 8 (33%) MSI-L, and 13 (28%) R ISS cancers (P = 0.0003), There was no association between MUC1 or MUC4 expression and MSI status. The mucinous phenotype described in serrated polyps (MUC2+/MUC5AC+) was seen in 15 (68%) of 22 MSI-H and only 10 (14%) of 71 MSI-L/MSS cancers (P < 0.0001), Increased expression of the secretory mucins MUC2 and MUC5AC was observed in sporadic MSI-H cancers. Identical mucin changes and DNA MSI occurred in serrated polyps of the colorectum, which suggests that these lesions may represent precursors of MSI-H cancers.
Keyword Oncology
Repeated Sequences Reveal
Dna-replication Errors
Tgf-beta Receptor
Monoclonal-antibodies
Serrated Adenomas
Clinicopathological Variables
Hyperplastic Polyps
Genetic Instability
Genomic Instability
Breast-cancer
Q-Index Code C1
Grant ID 1-UO1 CA74778
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 10 Jun 2008, 20:32:39 EST