Candidate targets for new antivirulence drugs: selected cases of bacterial adhesion and biofilm formation

Klemm, P., Hancock, V., Kvist, M. and Schembri, M. (2007) Candidate targets for new antivirulence drugs: selected cases of bacterial adhesion and biofilm formation. Future Microbiology, 2 6: 643-653. doi:10.2217/17460913.2.6.643


Author Klemm, P.
Hancock, V.
Kvist, M.
Schembri, M.
Title Candidate targets for new antivirulence drugs: selected cases of bacterial adhesion and biofilm formation
Journal name Future Microbiology   Check publisher's open access policy
ISSN 1746-0913
Publication date 2007-12-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2217/17460913.2.6.643
Volume 2
Issue 6
Start page 643
End page 653
Total pages 11
Place of publication United Kingdom
Publisher Future Medicine Ltd
Language eng
Subject 320401 Medical Bacteriology
C1
730101 Infectious diseases
Abstract Management of bacterial infections is becoming increasingly difficult due to the rising frequency of strains that are resistant to many current antibiotics. New types of antibiotics are, therefore, urgently needed. Virulence factors or virulence-associated phenotypes such as adhesins and biofilm formation are highly attractive targets for new drugs. Specific adhesion provides bacteria with target selection and prevents removal by hydrodynamic flow forces. Bacterial adhesion is of paramount importance for bacterial pathogenesis. Adhesion is also the first step in biofilm formation. Biofilm formation is particularly problematic in medical contexts because biofilm-associated bacteria are particularly hard to eradicate. Several promising candidate drugs that target bacterial adhesion and biofilm formation are being developed. Some of these might be valuable weapons for fighting infectious diseases in the future. Here we use illustrative examples, mainly from the enterics, to demonstrate the principles.
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
School of Chemistry and Molecular Biosciences
 
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Created: Fri, 02 May 2008, 02:12:39 EST by Darryl Greensill on behalf of School of Chemistry & Molecular Biosciences