Noradrenaline modulates transmission at a central synapse by a presynaptic mechanism

Delaney, Andrew J., Crane, James W. and Sah, Pankaj (2007) Noradrenaline modulates transmission at a central synapse by a presynaptic mechanism. Neuron, 56 5: 880-892. doi:10.1016/j.neuron.2007.10.022


Author Delaney, Andrew J.
Crane, James W.
Sah, Pankaj
Title Noradrenaline modulates transmission at a central synapse by a presynaptic mechanism
Formatted title
Noradrenaline modulates transmission at a central synapse by a presynaptic mechanism
Journal name Neuron   Check publisher's open access policy
ISSN 0896-6273
Publication date 2007-01-01
Sub-type Article (original research)
DOI 10.1016/j.neuron.2007.10.022
Volume 56
Issue 5
Start page 880
End page 892
Total pages 14
Editor K. Brose
E. Marcus
Place of publication United States
Publisher Cell Press
Collection year 2008
Language eng
Subject 320704 Cellular Nervous System
730104 Nervous system and disorders
C1
Abstract The lateral division of the central amygdala (CeAL) is the target of ascending fibers from the pain-responsive and stress-responsive nuclei in the brainstem. We show that single fiber inputs from the nociceptive pontine parabrachial nucleus onto CeAL neurons form suprathreshold glutamatergic synapses with multiple release sites. Noradrenaline, acting at presynaptic alpha2 receptors, potently inhibits this synapse. This inhibition results from a decrease in the number of active release sites with no change in release probability. Introduction of a presynaptic scavenger of Gbetagamma subunits blocked the effects of noradrenaline, and botulinum toxin A reduced its effects, showing a direct action of betagamma subunits on the release machinery. These data illustrate a mechanism of presynaptic modulation where the output of a large multiple-release-site synapse is potently regulated by endogenously released noradrenaline and suggests that the CeA may be a target for the central nociceptive actions of noradrenaline.
Keyword MOLNEURO
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Tue, 29 Apr 2008, 22:06:34 EST by Debra McMurtrie on behalf of Queensland Brain Institute