Albumin transport and processing by the proximal tubule: physiology and pathophysiology

Pollock C. A. and Poronnik, P. B. (2007) Albumin transport and processing by the proximal tubule: physiology and pathophysiology. Current Opinion in Nephrology and Hypertension, 16 4: 359-364. doi:10.1097/MNH.0b013e3281eb9059


Author Pollock C. A.
Poronnik, P. B.
Title Albumin transport and processing by the proximal tubule: physiology and pathophysiology
Journal name Current Opinion in Nephrology and Hypertension   Check publisher's open access policy
ISSN 1062-4821
Publication date 2007-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1097/MNH.0b013e3281eb9059
Open Access Status DOI
Volume 16
Issue 4
Start page 359
End page 364
Total pages 5
Editor Brenner, B. M.
Brown, T.
Place of publication Philadelphia
Publisher Lippincott Williams & Wilkins, Ltd.
Language eng
Subject C1
270104 Membrane Biology
780105 Biological sciences
Abstract Purpose of review Significant epidemiological and clinical trial evidence supports the association between increased urinary albumin excretion, cardiovascular events and renal failure. An increase in albumin excretion has traditionally been considered to reflect a 'glomerular' leak of protein; however, it is now recognized that significant tubular reabsorption of albumin occurs under physiological conditions that may be modified by genetic determinants, systemic disease and drug therapies. Recent findings The endocytosis of albumin by the proximal tubule is a highly regulated process depending on protein-protein interactions between several membrane proteins and scaffolding and regulatory molecules. The elucidation of these interactions is an ongoing research focus. There is also mounting evidence for a transcytotic pathway for retrieval of albumin from the tubular filtrate. The molecular basis for the role of albuminuria in both interstitial renal disease. and cardiovascular pathology continues to be defined. The clinical implications of albuminuria due to a glomerular leak vs: reduced tubular reabsorption of albumin area however;, now under consideration. In particular, the prognostic implication of microalbuminuria induced; by the more potent 3-hydroiy-3-methylglutaryl coenzyme A reductase inhibitors is under study: Summary The currently defined mechanisms underpinning the tubular reabsorption of albumin, how these are modified by pathology and pharmacology, and the clinical implications are the subject of this review.
Keyword Urology & Nephrology
Peripheral Vascular Disease
albumin trahscytosis
albuminuria
endocytosis
prenylation
Regulated Intramembrane Proteolysis
Monocyte Chemoattractant Protein-1
Receptor-mediated Endocytosis
Ppar-gamma Agonists
Epithelial-cells
Tubulointerstitial Injury
Overload Proteinuria
Urinary Protein
Clc Proteins
High Glucose
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
School of Biomedical Sciences Publications
 
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Created: Fri, 18 Apr 2008, 22:02:34 EST by Timothy Hazelton on behalf of School of Biomedical Sciences