Agenesis of the corpus callosum: genetic, developmental and functional aspects of connectivity

Paul, L. K., Brown, W. S., Adolphs, R., Tyszka J. M., Richards, L. J., Mukherjee, P. and Sherr, E. H. (2007) Agenesis of the corpus callosum: genetic, developmental and functional aspects of connectivity. Nature Reviews. Neuroscience, 8 4: 287-299. doi:10.1038/nrn2107


Author Paul, L. K.
Brown, W. S.
Adolphs, R.
Tyszka J. M.
Richards, L. J.
Mukherjee, P.
Sherr, E. H.
Title Agenesis of the corpus callosum: genetic, developmental and functional aspects of connectivity
Journal name Nature Reviews. Neuroscience   Check publisher's open access policy
ISSN 1471-003X
Publication date 2007-04-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrn2107
Volume 8
Issue 4
Start page 287
End page 299
Total pages 12
Editor Lopez, J. C.
Place of publication United Kingdom
Publisher Nature Publishing Group
Collection year 2008
Language eng
Subject C1
270210 Neurogenetics
780105 Biological sciences
Abstract Agenesis of the corpus callosum (AgCC), a failure to develop the large bundle of fibres that connect the cerebral hemispheres, occurs in 1: 4000 individuals. Genetics, animal models and detailed structural neuroimaging are now providing insights into the developmental and molecular bases of AgCC. Studies using neuropsychological, electroencephalogram and functional MRI approaches are examining the resulting impairments in emotional and social functioning, and have begun to explore the functional neuroanatomy underlying impaired higher-order cognition. The study of AgCC could provide insight into the integrated cerebral functioning of healthy brains, and may offer a model for understanding certain psychiatric illnesses, such as schizophrenia and autism.
Keyword Neurosciences
Potential Interhemispheric Transmission
Mowat-wilson-syndrome
Brain-development
Cell-adhesion
White-matter
Hemispheric-specialization
Language Representation
Sentence Comprehension
Disconnection Syndrome
Abnormal-development
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
School of Biomedical Sciences Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 295 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 314 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 18 Apr 2008, 21:24:08 EST by Timothy Hazelton on behalf of School of Biomedical Sciences