Amyloid peptides and proteins in review

Harrison, R. S., Sharpe, P. C., Singh, Y. and Fairlie, D. P. (2007). Amyloid peptides and proteins in review. In S. G. Amara, B. Bamberg, T. Fleischmann, S. C. Gudermann, S. C. Hebert, R. Jahn, W. J. Lederer, R. Lill, A. Miyajima, S. Offermanns and R. Zechner (Ed.), Reviews of physiology, biochemistry and pharmacology (pp. 1-77) Berlin, Germany: Springer. doi:10.1007/112_2007_0701


Author Harrison, R. S.
Sharpe, P. C.
Singh, Y.
Fairlie, D. P.
Title of chapter Amyloid peptides and proteins in review
Title of book Reviews of physiology, biochemistry and pharmacology
Language of Book Title eng
Place of Publication Berlin, Germany
Publisher Springer
Publication Year 2007
Sub-type Research book chapter (original research)
DOI 10.1007/112_2007_0701
Open Access Status Not yet assessed
Year available 2007
Series Reviews of Physiology, Biochemistry and Pharmacology
ISBN 978-3-540-73799-5
978-3-540-73800-8
ISSN 0303-4240
Editor S. G. Amara
B. Bamberg
T. Fleischmann
S. C. Gudermann
S. C. Hebert
R. Jahn
W. J. Lederer
R. Lill
A. Miyajima
S. Offermanns
R. Zechner
Volume number 159
Chapter number 1
Start page 1
End page 77
Total pages 78
Total chapters 4
Language eng
Subjects B1
320305 Medical Biochemistry - Proteins and Peptides
780103 Chemical sciences
0304 Medicinal and Biomolecular Chemistry
Abstract/Summary Amyloids are filamentous protein deposits ranging in size from nanometres to microns and composed of aggregated peptide β-sheets formed from parallel or anti-parallel alignments of peptide β-strands. Amyloid-forming proteins have attracted a great deal of recent attention because of their association with over 30 diseases, notably neurodegenerative conditions like Alzheimer's, Huntington's, Parkinson's, Creutzfeldt-Jacob and prion disorders, but also systemic diseases such as amyotrophic lateral sclerosis (Lou Gehrig's disease) and type II diabetes. These diseases are all thought to involve important conformational changes in proteins, sometimes termed misfolding, that usually produce β-sheet structures with a strong tendency to aggregate into water-insoluble fibrous polymers.
Keyword Amyloids
Peptides
Proteins
Neurodegenerative diseases
Q-Index Code B1
Institutional Status UQ
Additional Notes Also a journal series: ISSN 0303-4240; (Print) 1617-5786 (Online).

 
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