Making and breaking contacts: the cellular biology of cadherin regulation

Yap, A. S. K., Crampton, M. S. and Hardin, J. (2007) Making and breaking contacts: the cellular biology of cadherin regulation. Current Opinion in Cell Biology, 19 5: 508-514. doi:10.1016/

Author Yap, A. S. K.
Crampton, M. S.
Hardin, J.
Title Making and breaking contacts: the cellular biology of cadherin regulation
Journal name Current Opinion in Cell Biology   Check publisher's open access policy
ISSN 0955-0674
Publication date 2007-01-01
Year available 2007
Sub-type Article (original research)
DOI 10.1016/
Open Access Status Not yet assessed
Volume 19
Issue 5
Start page 508
End page 514
Total pages 7
Editor Hall, A.
Massague, J.
Place of publication London
Publisher Current Biology Ltd
Language eng
Subject C1
270105 Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)
780105 Biological sciences
Abstract Cadherin-mediated cell-cell interactions are dynamic processes, and cadherin function is tightly regulated in response to cellular context and signaling. Ultimately, cadherin regulation is likely to reflect the interplay between a range of fundamental cellular processes, including surface organization of receptors, cytoskeletal organization and cell trafficking, that are coordinated by signaling events. In this review we focus on recent advances in understanding how interplay with membrane trafficking and other cell-cell junctions can control cadherin function. The endocytosis of cadherins, and their post-internalization fate, influences surface expression and metabolic stability of these adhesion receptors. Similarly, at the surface, components of tight junctions provide a mode of cross-talk that regulates assembly of adherens junctions.
Keyword Cell Biology
Small G-proteins
Adherens Junctions
Dependent Endocytosis
Local Concentration
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID GM58038
Institutional Status UQ

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Created: Thu, 10 Apr 2008, 23:52:25 EST by Jennifer Greder on behalf of Institute for Molecular Bioscience