Genetic susceptibility to environmental toxicants: the interface between human and experimental studies in the development of new toxicological concepts

Thier, R, Golka, K, Bruning, T, Ko, Y and Bolt, HM (2002) Genetic susceptibility to environmental toxicants: the interface between human and experimental studies in the development of new toxicological concepts. Toxicology Letters, 127 1-3: 321-327. doi:10.1016/S0378-4274(01)00515-X


Author Thier, R
Golka, K
Bruning, T
Ko, Y
Bolt, HM
Title Genetic susceptibility to environmental toxicants: the interface between human and experimental studies in the development of new toxicological concepts
Journal name Toxicology Letters   Check publisher's open access policy
ISSN 0378-4274
Publication date 2002-01-01
Sub-type Article (original research)
DOI 10.1016/S0378-4274(01)00515-X
Open Access Status DOI
Volume 127
Issue 1-3
Start page 321
End page 327
Total pages 7
Place of publication Clare
Publisher Elsevier Sci Ireland Ltd
Language eng
Subject 3005 Toxicology
Abstract The growing knowledge of the genetic polymorphisms of enzymes metabolising xenobiotics in humans and their connections with individual susceptibility towards toxicants has created new and important interfaces between human epidemiology and experimental toxicology. The results of molecular epidemiological studies may provide new hypotheses and concepts, which call for experimental verification, and experimental concepts may obtain further proof by molecular epidemiological studies. If applied diligently, these possibilities may be combined to lead to new strategies of human-oriented toxicological research. This overview will present some outstanding examples for such strategies taken from the practically very important field of occupational toxicology. The main focus is placed on the effects of enzyme polymorphisms of the xenobiotic metabolism in association with the induction of bladder cancer and renal cell cancer after exposure to occupational chemicals. Also, smoking and induction of head and neck squamous cell cancer are considered. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Keyword Toxicology
genetic susceptibility
metabolism
cancer
Renal-cell Cancer
Occupational Exposure
Epithelial-cells
Tubular Damage
Bladder-cancer
Urinary-tract
B6c3f1 Mice
Trichloroethylene
Carcinogenicity
Toxicity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
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Created: Sat, 29 Mar 2008, 01:19:41 EST