No association between serum 25-Hydroxyvitamin D3 level and performance on psychometric tests in NHANes III

McGrath, J. J., Scragg, R., Chant, D. C., Eyles, D., Burne, T. H. J. and Obradovic, D. (2007) No association between serum 25-Hydroxyvitamin D3 level and performance on psychometric tests in NHANes III. Neuroepidemiology, 29 1-2: 49-54. doi:10.1159/000108918


Author McGrath, J. J.
Scragg, R.
Chant, D. C.
Eyles, D.
Burne, T. H. J.
Obradovic, D.
Title No association between serum 25-Hydroxyvitamin D3 level and performance on psychometric tests in NHANes III
Journal name Neuroepidemiology   Check publisher's open access policy
ISSN 0251-5350
Publication date 2007-01-01
Sub-type Article (original research)
DOI 10.1159/000108918
Volume 29
Issue 1-2
Start page 49
End page 54
Total pages 6
Editor Roman, G. C.
Place of publication Basel, Switzerland
Publisher S. Karger AG
Collection year 2008
Language eng
Subject 321204 Mental Health
C1
730211 Mental health
Abstract Background: Animal studies and in vitro experiments indicate that vitamin D is involved in a diverse range of neurobiological functions. We had the opportunity to examine the relationship between serum 25-hydroxyvitamin D 3 [25( OH) D] levels and performance on various cognitive tasks, based on a large, representative community sample. Methods: Three age groups were available from the population-based NHANES III survey: adolescent group (n = 1,676, age range 12 - 17 years), adult group (n = 4,747, 20 - 60 years), elderly group (n = 4,809, 60 - 90 years). The associations between eight psychometric measures and serum 25(OH) D were assessed. Results: In the adolescent and adult groups, none of the psychometric measures were associated with 25(OH) D levels. In the elderly group there was a significant difference between 25(OH) D quintiles performance on a learning and memory task; however, those with the highest quintile of 25(OH) D were most impaired on the task, contrary to the hypotheses. Conclusion: Lower 25(OH) D levels were not associated with impaired performance on various psychometric measures. While it remains to be seen if chronic exposure to low 25( OH) D levels alters brain function in the long term, this cross-sectional study suggests that 25( OH) D levels do not influence neurocognitive performance.
Keyword Public, Environmental & Occupational Health
Clinical Neurology
vitamin D
cognition
epidemiology
Vitamin-d Deficiency
Nutrition Examination Survey
3rd National-health
Nervous-system
Hippocampal-neurons
Physical-activity
Gene-expression
Adult Rats
Hormone
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2008 Higher Education Research Data Collection
School of Biomedical Sciences Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 78 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 78 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 28 Mar 2008, 23:43:53 EST by Carmel Meir on behalf of School of Medicine