Growth cone chemotaxis

Mortimer, Duncan, Fothergill, Thomas, Pujic, Zac, Richards, Linda J. and Goodhill, Geoffrey J. (2008) Growth cone chemotaxis. Trends in Neurosciences, 31 2: 90-98. doi:10.1016/j.tins.2007.11.008


Author Mortimer, Duncan
Fothergill, Thomas
Pujic, Zac
Richards, Linda J.
Goodhill, Geoffrey J.
Title Growth cone chemotaxis
Journal name Trends in Neurosciences   Check publisher's open access policy
ISSN 0166-2236
Publication date 2008-01-01
Year available 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.tins.2007.11.008
Volume 31
Issue 2
Start page 90
End page 98
Total pages 9
Editor Lewis, Sian
Place of publication United Kingdom
Publisher Elsevier Ltd., Trends Journals
Language eng
Subject C1
110902 Cellular Nervous System
110903 Central Nervous System
920111 Nervous System and Disorders
Abstract Wiring up the nervous system depends on the precise guidance of axonal growth cones to their targets. A key mechanism underlying this guidance is chemotaxis, whereby growth cones detect and follow molecular gradients. Although recent work has uncovered many of the molecules involved in this process, the mechanisms underlying chemotactic axon guidance are still unclear. Here we compare growth cones with neutrophils and Dictyostelium discoideum, systems for which a clear conceptual framework for chemotaxis has recently emerged. This analogy suggests particular ways in which the three key steps of directional sensing, polarisation and motility might be implemented in chemotaxing growth cones.
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2009 Higher Education Research Data Collection
Excellence in Research Australia (ERA) - Collection
Queensland Brain Institute Publications
School of Biomedical Sciences Publications
 
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Created: Wed, 19 Mar 2008, 19:49:58 EST