Symptomatic and asymptomatic viral recrudescence in solid-organ transplant recipients and its relationship with the antigen-specific CD8+ T-cell response

Crough, Tania, Fazou, Chrysa, Weiss, Julissa, Campbell, Scott, Davenport, Miles P., Bell, Scott C., Galbraith, Andrew, McNeil, Keith and Khanna, Rajiv (2007) Symptomatic and asymptomatic viral recrudescence in solid-organ transplant recipients and its relationship with the antigen-specific CD8+ T-cell response. Journal of Virology, 81 20: 11538-11542. doi:10.1128/JVI.00581-07

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Author Crough, Tania
Fazou, Chrysa
Weiss, Julissa
Campbell, Scott
Davenport, Miles P.
Bell, Scott C.
Galbraith, Andrew
McNeil, Keith
Khanna, Rajiv
Title Symptomatic and asymptomatic viral recrudescence in solid-organ transplant recipients and its relationship with the antigen-specific CD8+ T-cell response
Journal name Journal of Virology   Check publisher's open access policy
ISSN 0022-538X
1098-5514
Publication date 2007-10-01
Year available 2007
Sub-type Article (original research)
DOI 10.1128/JVI.00581-07
Open Access Status File (Publisher version)
Volume 81
Issue 20
Start page 11538
End page 11542
Total pages 5
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Collection year 2008
Language eng
Subject 320205 Transplantation Immunology
730102 Immune system and allergy
C1
Abstract Using ex vivo antigen-specific T-cell analysis, we found that symptomatic cytomegalovirus recrudescence in transplant recipients was coincident with reduced expression of gamma interferon (IFN-{gamma}) by virus-specific CD8+ T cells and an up-regulation of CD38 expression on these T cells, although there was no significant change in the absolute number of virus-specific cells (as assessed by major histocompatibility complex-peptide multimers). In contrast, HLA class I-matched transplant patients with asymptomatic viral recrudescence showed increased expansion of antigen-specific T cells and highly stable IFN-{gamma} expression by epitope-specific T cells. These studies suggest that a strong functional T-cell response plays a crucial role in defining the clinical outcome of acute viral recrudescence.
Keyword Virology
Human Cytomegalovirus
Immune-responses
Virus-infection/
Vivo
Cd4(+)
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Fri, 07 Mar 2008, 20:50:07 EST by Sarah Elliott on behalf of Medicine - Prince Charles Hospital