The time course and determinants of temperature within the first 48 h after ischaemic stroke

Wong, A. A., Davis, J. P., Schluter, P. J., Henderson, R. D., O'Sullivan, J. D. and Read, S. J. (2007) The time course and determinants of temperature within the first 48 h after ischaemic stroke. Cerebrovascular Diseases, 24 1: 104-110. doi:10.1159/000103124

Author Wong, A. A.
Davis, J. P.
Schluter, P. J.
Henderson, R. D.
O'Sullivan, J. D.
Read, S. J.
Title The time course and determinants of temperature within the first 48 h after ischaemic stroke
Journal name Cerebrovascular Diseases   Check publisher's open access policy
ISSN 1015-9770
Publication date 2007-01-01
Year available 2007
Sub-type Article (original research)
DOI 10.1159/000103124
Open Access Status Not Open Access
Volume 24
Issue 1
Start page 104
End page 110
Total pages 7
Editor J. Bogousslavsky
M. Hennerici
Place of publication Basel, Switzerland
Publisher S. Karger AG
Language eng
Subject C1
320100 Medicine - General
730000 - Health
Formatted abstract
BACKGROUND AND PURPOSE: Previous research has attempted to analyze the relationship between post-stroke hyperthermia and prognosis. These analyses have been hindered by a lack of information about the time course and determinants of temperature change after stroke. METHODS: Serial temperatures were measured until 48 h after ischaemic stroke in a prospectively recruited cohort. Potential determinants of temperature, including stroke severity [measured using the National Institutes of Health Stroke Scale (NIHSS)], infection and paracetamol use were recorded. Mixed-effects models were used to model serial temperature measurements over time, adjusted for significant determinants. RESULTS: In 155 patients the mean temperature rose from 36.5 degrees C at the time of stroke to 36.7 degrees C approximately 36 h later. The factors with significant multivariable associations with serial temperatures were: first- and second-order time components, infection, paracetamol administration and the interaction between stroke severity (NIHSS > or =6) and time (all p < 0.1). Patients with admission NIHSS > or =6 had a mean temperature rise of 0.35 degrees C during the first 36 h after stroke, compared with a rise of 0.17 degrees C in those with NIHSS < or =5. CONCLUSIONS: Temperature spontaneously rises during the first 36 h after stroke, particularly after severer stroke and in the presence of infection.
Keyword Stroke
Ischaemic stroke
National Institute of Health Stroke Scale
Mixed-effects models
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Mon, 03 Mar 2008, 21:31:52 EST