Implications of the obesity epidemic for statin therapy: shifting cholesterol metabolism to a high synthesis and low dietary absorption state

Hoenig, M. R., Kostner, K. M., Read, S. J., Walker, P. J. and Atherton, J. J. (2007) Implications of the obesity epidemic for statin therapy: shifting cholesterol metabolism to a high synthesis and low dietary absorption state. Endocrine, Metabolic & Immune Disorders - Drug Targets, 7 3: 153-166. doi:10.2174/187153007781662567


Author Hoenig, M. R.
Kostner, K. M.
Read, S. J.
Walker, P. J.
Atherton, J. J.
Title Implications of the obesity epidemic for statin therapy: shifting cholesterol metabolism to a high synthesis and low dietary absorption state
Journal name Endocrine, Metabolic & Immune Disorders - Drug Targets   Check publisher's open access policy
ISSN 1871-5303
Publication date 2007-01-01
Sub-type Article (original research)
DOI 10.2174/187153007781662567
Volume 7
Issue 3
Start page 153
End page 166
Total pages 14
Editor E. Jirillo
M. J. Quon
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Language eng
Subject 321003 Cardiology (incl. Cardiovascular Diseases)
730106 Cardiovascular system and diseases
C1
110201 Cardiology (incl. Cardiovascular Diseases)
Abstract Obesity and the metabolic syndrome are becoming one of the biggest health challenges of the 21(st) century. Cholesterol metabolism is significantly altered in both obesity and metabolic syndrome in that cholesterol synthesis is increased and absorption reduced and this has important implications for the treatment of lipid disorders in both obesity and the metabolic syndrome. In the present review we discuss these changes in detail especially in the context of a more standardized approach for cholesterol reduction like the TARGET LDL trial. Customized care is topical in lipidology as we strive to achieve LDL cholesterol and non-HDL cholesterol targets in every patient
Keyword Animals
Cholesterol/biosynthesis/*metabolism
Cholesterol, LDL/metabolism
Diabetes Mellitus/epidemiology/genetics
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
Intestinal Absorption/*drug effects
Metabolic Syndrome X/metabolism
Obesity/*epidemiology/genetics/metabolism
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Mon, 03 Mar 2008, 21:24:58 EST