Inhibition and synchronization of basal amygdala principal neuron spiking by parvalbumin-positive interneurons

Woodruff, Alan R. and Sah, Pankaj (2007) Inhibition and synchronization of basal amygdala principal neuron spiking by parvalbumin-positive interneurons. Journal of Neurophysiology, 98 5: 2956-2961. doi:10.1152/jn.00739.2007


Author Woodruff, Alan R.
Sah, Pankaj
Title Inhibition and synchronization of basal amygdala principal neuron spiking by parvalbumin-positive interneurons
Journal name Journal of Neurophysiology   Check publisher's open access policy
ISSN 0022-3077
Publication date 2007-11-01
Sub-type Article (original research)
DOI 10.1152/jn.00739.2007
Volume 98
Issue 5
Start page 2956
End page 2961
Total pages 6
Editor B. B. Rauner
P. L. Strick
et al.
Place of publication Bethesda, MD
Publisher American Physiological Society
Collection year 2008
Language eng
Subject 320704 Cellular Nervous System
C1
730104 Nervous system and disorders
Abstract Using mice that express enhance green fluorescent protein (EGFP) under the control of the parvalbumin promoter, we made paired recordings from interneurons and principal neurons in the basal amygdala. In synaptically connected pairs, we show that single action potentials in a parvalbumin expressing interneuron can inhibit spiking in the synaptically connected principal neuron. When principal neurons were provided with suprathreshold oscillatory drive via a somatic patch pipette, action potentials in the interneuron inhibited spiking in principal neurons only when the interneuron spike occurred shortly before excitation reached threshold in the principal neuron. Moreover, after this spike inhibition, there was a rebound excitation in the principal neurons that was seen as an increased probability of firing on the cycle after inhibition. These results illustrate the major role of local inhibition in the basal amygdala. We propose that these interneurons in the basal amygdala provide a potent inhibition that acts to inhibit firing of principal neurons during cortically driven oscillations.
Keyword Neurosciences
Physiology
Rat Basolateral Amygdala
In-vivo
Immunohistochemical Characterization
Gabaergic Interneurons
Oscillations
Hippocampus
Cells
Networks
State
Synapses
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Tue, 19 Feb 2008, 01:39:00 EST