Synthesis and characterization of the tetranuclear iron(III) complex of a new asymmetric multidentate ligand. A structural model for purple acid phosphatases

Boudalis, Athanassios K., Aston, Robyn E., Smith, Sarah J., Mirams, Ruth E., Riley, Mark J., Schenk, Gerhard, Blackman, Allan G., Hanton, Lyall R. and Gahan, Lawrence R. (2007) Synthesis and characterization of the tetranuclear iron(III) complex of a new asymmetric multidentate ligand. A structural model for purple acid phosphatases. Dalton Transactions, 2007 44: 5132-5139. doi:10.1039/b709293h

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Author Boudalis, Athanassios K.
Aston, Robyn E.
Smith, Sarah J.
Mirams, Ruth E.
Riley, Mark J.
Schenk, Gerhard
Blackman, Allan G.
Hanton, Lyall R.
Gahan, Lawrence R.
Title Synthesis and characterization of the tetranuclear iron(III) complex of a new asymmetric multidentate ligand. A structural model for purple acid phosphatases
Journal name Dalton Transactions   Check publisher's open access policy
ISSN 1477-9226
Publication date 2007-09-06
Year available 2007
Sub-type Article (original research)
DOI 10.1039/b709293h
Open Access Status File (Publisher version)
Volume 2007
Issue 44
Start page 5132
End page 5139
Total pages 8
Place of publication Cambridge
Publisher RSC Publications
Collection year 2008
Language eng
Subject C1
780103 Chemical sciences
270108 Enzymes
250302 Biological and Medical Chemistry
250204 Bioinorganic Chemistry
Abstract The ligand, 2-((2-hydroxy-5-methyl-3-((pyridin-2-ylmethylamino)methyl)benzyl)(2-hydroxybenzyl)amino)acetic acid (H(3)HPBA), which contains a donor atom set that mimics that of the active site of purple acid phosphatase is described. Reaction of H(3)HPBA with iron(III) or iron(II) salts results in formation of the tetranuclear complex, [Fe-4(HPBA)(2)(OAc)(2)(mu-O)(mu-OH)(OH2)(2)]ClO4 center dot 5H(2)O. X-Ray structural analysis reveals the cation consists of four iron(III) ions, two HPBA(3-) ligands, two bridging acetate ligands, a bridging oxide ion and a bridging hydroxide ion. Each binucleating HPBA(3-) ligand coordinates two structurally distinct hexacoordinate iron(III) ions. The two metal ions coordinated to a HPBA(3-) ligand are linked to the two iron(III) metal ions of a second, similar binuclear unit by intramolecular oxide and hydroxide bridging moieties to form a tetramer. The complex has been further characterised by elemental analysis, mass spectrometry, UV-vis and MCD spectroscopy, X- ray crystallography, magnetic susceptibility measurements and variable-temperature Mossbauer spectroscopy.
Keyword Chemistry, Inorganic & Nuclear
Crystal-structure
Magnetic-properties
Electrochemical Properties
Dinucleating Ligand
Manganese Cluster
Photosystem-ii
Oxo Proteins
Amino-acids
Active-site
Iron-oxo
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Tue, 19 Feb 2008, 01:35:33 EST