Associations of sitting time with components of the metabolic syndrome in adults without diagnosed diabetes - The AusDiab Study

Dunstan, D. W., Owen, N., Salmon, J., Healy, G., Ball, K., Shaw, J. E. and Zimmet, P. Z. (2006). Associations of sitting time with components of the metabolic syndrome in adults without diagnosed diabetes - The AusDiab Study. In: E. Gale, Abstracts of the 42nd General Assembly of the European Association for the Study of Diabetes. 42nd General Assembly of the European Association for the Study of Diabetes, Copenhagen, Denmark, (S125-S125). 16 September 2006. doi:10.1007/s00125-007-0809-7


Author Dunstan, D. W.
Owen, N.
Salmon, J.
Healy, G.
Ball, K.
Shaw, J. E.
Zimmet, P. Z.
Title of paper Associations of sitting time with components of the metabolic syndrome in adults without diagnosed diabetes - The AusDiab Study
Conference name 42nd General Assembly of the European Association for the Study of Diabetes
Conference location Copenhagen, Denmark
Conference dates 16 September 2006
Proceedings title Abstracts of the 42nd General Assembly of the European Association for the Study of Diabetes   Check publisher's open access policy
Journal name Diabetologia   Check publisher's open access policy
Place of Publication Berlin & Heidelberg
Publisher Springer
Publication Year 2006
Sub-type Published abstract
DOI 10.1007/s00125-007-0809-7
ISSN 0012-186X
1432-0428
Editor E. Gale
Volume 50
Issue Supp 1
Start page S125
End page S125
Total pages 1
Language eng
Formatted Abstract/Summary
Background and Aims: Several studies have shown that sedentary behaviour may be an important contributor to poor health outcomes. However, most studies have focused on leisure time behaviours such as time spent watching television. Less is known about the association of sedentary behaviours in both leisure and non-leisure time on metabolic outcomes. We have examined the associations of self-reported time spent sitting and components of the metabolic syndrome in Australian adults without diabetes.

Materials and Methods: 
The Australian Diabetes, Obesity and Lifestyle Study (AusDiab) is a nationally representative population-based survey of 11,247 adults aged 25 years with baseline measurements obtained between 1999 and 2000. The present analyses include a total of 5,749 adults who attended the 5-year follow-up and who were free from diagnosed diabetes. Fasting measures of plasma glucose, serum triglycerides and HDL-C and 2hrPG were obtained from an oral glucose tolerance test. Self-reported time spent sitting (hrs/day) was assessed using an interviewer-administered questionnaire.

Waist circumference, height and resting blood pressure were measured at the testing site. The log transformation of the triglyceride measure was used in the analysis. All regression models were adjusted for age, education, employment status and physical activity time. Data are presented as regression coefficients (95% CI).

Results:
The mean (SD) sitting time (hrs/day) for women and men was 5.1 (2.6) and 5.5 (2.7) respectively. In both men and women, sitting time was positively associated with 2hrPG , log-transformed triglycerides, and waist circumference and inversely associated with HDL-C (P value range: 0.001–0.01). The mean differences between the top tertile and bottom tertile were: 2hrPG [men: 0.2 mmol/l (0.01 to 0.40), women 0.3 mmol/l (0.14 to 0.44)], log-transformed triglycerides [men 0.1 (0.05 to 0.16), women 0.1 (0.06 to 0.14)], waist [men 2.4 cm (1.3 to 3.4), women 3.3 cm (2.2 to 4.4)] and HDL-C [men –0.06 mmol/l (–0.09 to –0.03), women (–0.05 mmol/l (–0.09 to –0.02)].

Systolic and diastolic blood pressure were positively associated with sitting time in women only (both P = 0.01). No association was observed with FBG.

The associations observed for 2hrPG and log-triglycerides in women and logtriglycerides and HDL-C in men remained significant (P < 0.003) following further adjustment for waist circumference. In regression models containing both weekday and weekend sitting time as covariates, weekday sitting time was associated with log-triglycerides in men and women (both P < 0.01) and HDL-C and waist in men (P < 0.001). Weekend sitting time was associated with 2hrPG in both men and women (both P < 0.05) and log-triglycerides (P = 0.04) and waist (P = 0.001) in women.

Conclusion:
  These findings highlight the unique deleterious relationships of sedentary behaviour (indicated by sitting time) and components of the metabolic syndrome, independent of physical activity time. Population strategies to reduce the risk of developing the metabolic syndrome should focus not only on increasing physical activity, but also on reducing sedentary behaviours, such as time spent sitting.
Subjects 11 Medical and Health Sciences
Keyword Endocrinology and metabolism
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Conference Paper
Collection: School of Public Health Publications
 
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Created: Tue, 19 Feb 2008, 01:03:06 EST