Clinical applications and new developments of optical coherence tomography: an evidence-based review

Chen, Jennifer and Lee, Lawrence (2007) Clinical applications and new developments of optical coherence tomography: an evidence-based review. Clinical and Experimental Optometry, 90 5: 317-335. doi:10.1111/j.1444-0938.2007.00151.x


Author Chen, Jennifer
Lee, Lawrence
Title Clinical applications and new developments of optical coherence tomography: an evidence-based review
Journal name Clinical and Experimental Optometry   Check publisher's open access policy
ISSN 1444-0938
0816-4622
Publication date 2007-09-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1444-0938.2007.00151.x
Volume 90
Issue 5
Start page 317
End page 335
Total pages 19
Place of publication Carlton, Victoria
Publisher Australian Optometrical Association
Language eng
Subject 1113 Ophthalmology and Optometry
1103 Clinical Sciences
Abstract Optical coherence tomography (OCT) is a new imaging modality that has increasingly become an indispensable tool in clinical practice for the diagnosis and management of ocular diseases involving the macula, optic nerve and anterior segment. The instrument is an advanced imaging technique that provides unprecedented high resolution and cross-sectional tomographic images of the ocular microstructure in situ, and in real time. Since its introduction about four years ago, a multitude of advantages has made OCT an essential instrument in ophthalmic imaging. The technique has fast image acquisition speed and non-contact, non-invasive applicability, allowing a non-excisional 'optical biopsy' to be performed. The purpose of this paper is to provide an evidence-based review of the increasing role of OCT in the diagnosis and management of ocular disorders, particularly in age-related macular degeneration, diabetic macular oedema, macular hole, epiretinal membrane and glaucoma. Being one of the first users of OCT in Australia, our clinical experiences will be highlighted and clinical examples of various conditions will be presented to provide an overview of the immense implications of OCT in practice. The latest developments of the OCT revolution, in relation to combining OCT with fundus photography and scanning laser ophthalmoscopy, will also be described. New developments of three-dimensional visualisation of tissue morphology with future models of ultra-high speed, ultra-high resolution OCT may further enhance the early diagnosis, monitoring of disease progression and assessment of treatment efficacy, facilitated by this powerful technology.
Keyword Ophthalmology
diagnostic imaging
macula
optical coherence tomography
optic nerve
retina
Nerve-fiber Layer
Diabetic Macular Edema
Scanning Laser Polarimetry
Intravitreal Bevacizumab Avastin
Vitreomacular Traction Syndrome
Fundus Fluorescein Angiography
Monitor Photodynamic Therapy
Retinal Thickness Analysis
In-situ Keratomileusis
Ultrahigh-resolution
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Tue, 19 Feb 2008, 00:49:20 EST