Indole-3-carbinol - Induced growth inhibition can be converted to a cytotoxic response in the presence of TPA+Ca2+ in squamous cell carcinoma cell lines

Dahler, A. L., Rickwood, D., Guminski, A., Teakle, N. and Saunders, N. A. (2007) Indole-3-carbinol - Induced growth inhibition can be converted to a cytotoxic response in the presence of TPA+Ca2+ in squamous cell carcinoma cell lines. FEBS Letters (Federation of European Biochemical Socities), 581 20: 3839-3847. doi:10.1016/j.febslet.2007.07.009


Author Dahler, A. L.
Rickwood, D.
Guminski, A.
Teakle, N.
Saunders, N. A.
Title Indole-3-carbinol - Induced growth inhibition can be converted to a cytotoxic response in the presence of TPA+Ca2+ in squamous cell carcinoma cell lines
Journal name FEBS Letters (Federation of European Biochemical Socities)   Check publisher's open access policy
ISSN 0014-5793
1873-3468
Publication date 2007-08-01
Sub-type Article (original research)
DOI 10.1016/j.febslet.2007.07.009
Open Access Status
Volume 581
Issue 20
Start page 3839
End page 3847
Total pages 9
Place of publication Amsterdam, Netherlands
Publisher Elsevier Science
Language eng
Subject 11 Medical and Health Sciences
Abstract We examined the possibility that 13C, when combined with a differentiation stimulus (TPA + CaCl2), would sensitise SCC cells to a differentiation stimulus. We report that 13C induces a profound growth inhibition in SCC cells that is dissimilar to the growth inhibition required to initiate differentiation. Moreover, we report that 13C, when combined with TPA + CaCl2 treatment, induces a loss of colony forming ability that was differentiation and senescence - independent but was due to delayed cytotoxicity. This study shows that 13C in combination with a PKC activator + Ca2+ may be a useful therapeutic strategy for treating oral SCC. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Keyword Biochemistry & Molecular Biology
Biophysics
Cell Biology
squamous cell carcinoma
indole-3-carbinol
squamous differentiation
keratinocyte
Human Epidermal-keratinocytes
Differentiation-specific Genes
Breast-cancer Cells
Cycle Arrest
Interferon-gamma
Expression
E2f
Sufficient
Senescence
Apoptosis
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 19 Feb 2008, 00:47:12 EST