Plasmodium strain determines dendritic cell function essential for survival from malaria

Wykes, Michelle N., Liu, Xue Q., Beattie, Lynette, Stanisic, Danielle I., Stacey, Katryn J., Smyth, Mark J., Thomas, Ranjeny and Good, Michael F. (2007) Plasmodium strain determines dendritic cell function essential for survival from malaria. PLoS Pathogens, 3 7: e96-0904-e96-0912. doi:10.1371/journal.ppat.0030096


Author Wykes, Michelle N.
Liu, Xue Q.
Beattie, Lynette
Stanisic, Danielle I.
Stacey, Katryn J.
Smyth, Mark J.
Thomas, Ranjeny
Good, Michael F.
Title Plasmodium strain determines dendritic cell function essential for survival from malaria
Journal name PLoS Pathogens   Check publisher's open access policy
ISSN 1553-7366
1553-7366
Publication date 2007-07-01
Sub-type Article (original research)
DOI 10.1371/journal.ppat.0030096
Open Access Status DOI
Volume 3
Issue 7
Start page e96-0904
End page e96-0912
Total pages 9
Place of publication San Francisco, C.A., U.S.A.
Publisher Public Library of Science
Language eng
Subject C1
110309 Infectious Diseases
110803 Medical Parasitology
110322 Rheumatology and Arthritis
1107 Immunology
Abstract The severity of malaria can range from asymptomatic to lethal infections involving severe anaemia and cerebral disease. However, the molecular and cellular factors responsible for these differences in disease severity are poorly understood. Identifying the factors that mediate virulence will contribute to developing antiparasitic immune responses. Since immunity is initiated by dendritic cells (DCs), we compared their phenotype and function following infection with either a nonlethal or lethal strain of the rodent parasite, Plasmodium yoelii, to identify their contribution to disease severity. DCs from nonlethal infections were fully functional and capable of secreting cytokines and stimulating T cells. In contrast, DCs from lethal infections were not functional. We then transferred DCs from mice with nonlethal infections to mice given lethal infections and showed that these DCs mediated control of parasitemia and survival. IL-12 was necessary for survival. To our knowledge, our studies have shown for the first time that during a malaria infection, DC function is essential for survival. More importantly, the functions of these DCs are determined by the strain of parasite. Our studies may explain, in part, why natural malaria infections may have different outcomes. © 2007 Wykes et al.
Keyword Infectious diseases
Microbiology
Parasitology
Falciparum-infected erythrocytes
Chabaudi-chabaudi infection
Blood-stage parasites
Susceptible A/j mice
Regulatory T-cells
Protective immunity
Chondroitin sulfate
Ifn-gamma
B-cells
Receptor
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Tue, 19 Feb 2008, 00:36:16 EST