Investigation of factors relating to neuropsychological change following cardiac surgery

Raymond, P. D., Radel, M., Ray, M. J., Hinton-Bayre, A. D. and Marsh, N. A. (2007) Investigation of factors relating to neuropsychological change following cardiac surgery. Perfusion-uk, 22 1: 27-33. doi:10.1177/0267659107077952


Author Raymond, P. D.
Radel, M.
Ray, M. J.
Hinton-Bayre, A. D.
Marsh, N. A.
Title Investigation of factors relating to neuropsychological change following cardiac surgery
Journal name Perfusion-uk   Check publisher's open access policy
ISSN 0267-6591
Publication date 2007-01-01
Sub-type Article (original research)
DOI 10.1177/0267659107077952
Open Access Status Not yet assessed
Volume 22
Issue 1
Start page 27
End page 33
Total pages 7
Place of publication London
Publisher Sage Publications Ltd
Language eng
Subject C1
Abstract Background. An analysis of neuropsychological impairment following cardiopulmonary bypass was performed in 55 patients undergoing elective coronary artery bypass grafting. Methods. Neurocognitive function was measured preoperatively using the MicroCog: Assessment of Cognitive Functioning computer-based testing too]. Testing was repeated in the postoperative period immediately prior to discharge from hospital. Analysis of significant score decline was performed using the standardised regression-based technique. A patient was classified as overall impaired when >= 20% of test scores were significantly impaired. The proposed marker of neurological damage S-100 beta was also used. Prothrombin Fragment 1+2 (F1+2) was measured as a marker of thrombin development to test the hypothesis that excessive haemostatic activation may lead to thromboembolic damage to the brain. Results and Conclusions. 32.7% of patients were classified as significantly impaired. No relationship was detected between F1+2 and any neuropsychological test score; however, the study was limited due to small sample size. F1 + 2 levels were higher in patients undergoing prolonged bypass times. Neuropsychological decline was significantly correlated with patient age, suggesting a degree of caution is warranted when operating on an elderly cohort. An unexpected relationship was detected between higher heparin concentrations and increased risk of neuropsychological impairment; however, this requires re-evaluation.
Keyword Peripheral Vascular Disease
cardiopulmonary bypass
neurocognitive deficits
cerebral complications
coagulation
heparin
Coronary-artery-bypass
Reliable Change Indexes
Cardiopulmonary Bypass
S-100 Protein
Cardiotomy Suction
Test-performance
Cerebral Injury
Serum
Release
Marker
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Journal Article Import (ISI/CVs)
2008 Higher Education Research Data Collection
 
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Created: Tue, 19 Feb 2008, 00:13:34 EST