Maternal vitamin D depletion alters neurogenesis in the developing rat brain

Cui, X. Y., McGrath, J. J., Burne, T. H. J., Mackay-Sim, A. and Eyles, D. W. (2007) Maternal vitamin D depletion alters neurogenesis in the developing rat brain. International Journal of Developmental Neuroscience, 25 4: 227-232. doi:10.1016/j.ijdevneu.2007.03.006

Author Cui, X. Y.
McGrath, J. J.
Burne, T. H. J.
Mackay-Sim, A.
Eyles, D. W.
Title Maternal vitamin D depletion alters neurogenesis in the developing rat brain
Journal name International Journal of Developmental Neuroscience   Check publisher's open access policy
ISSN 0736-5748
Publication date 2007-06-01
Year available 2007
Sub-type Article (original research)
DOI 10.1016/j.ijdevneu.2007.03.006
Open Access Status Not yet assessed
Volume 25
Issue 4
Start page 227
End page 232
Total pages 6
Editor J. Regino Perez-Polo
Place of publication Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Subject C1
320799 Neurosciences not elsewhere classified
780105 Biological sciences
1109 Neurosciences
Abstract Evidence is accumulating that normal levels of vitamin D are important for brain development. Vitamin D acts as an anti-proliferative agent in a wide variety of tissues and developmental vitamin D (DVD) deficiency has been shown to alter brain structure and function. The aim of this study was to investigate the effect of DVD deficiency on neuroprogenitor formation in the neonatal brain. We show that DVD deficiency increased the number of neurospheres formed in cultures from the neonatal subventricular zone. Exogenous vitamin D added to the culture medium reduced neurosphere number in control but not DVD cultures. We show the receptor for vitamin D is concentrated in the subventricular zone and is also present in cultured neurospheres prepared from this region. These results show that vitamin D can regulate cell proliferation in the developing brain. Further studies are warranted to examine the underlying mechanisms for these findings. (c) 2007 ISDN. Published by Elsevier Ltd. All rights reserved.
Keyword Subventricular zone
Vitamin D deficiency
Neurosphere assay
Brain development
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Tue, 19 Feb 2008, 03:35:42 EST