Predictable alpha beta T-cell receptor selection toward an HLA-B*3501-Restricted human cytomegalovirus epitope

Brennan, Rebekah M., Miles, John J., Silins, Sharon L., Bell, Melissa J., Burrows, Jacqueline M. and Burrows, Scott R. (2007) Predictable alpha beta T-cell receptor selection toward an HLA-B*3501-Restricted human cytomegalovirus epitope. Journal of Virology, 81 13: 7269-7273. doi:10.1128/JVI.00356-07

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Author Brennan, Rebekah M.
Miles, John J.
Silins, Sharon L.
Bell, Melissa J.
Burrows, Jacqueline M.
Burrows, Scott R.
Title Predictable alpha beta T-cell receptor selection toward an HLA-B*3501-Restricted human cytomegalovirus epitope
Journal name Journal of Virology   Check publisher's open access policy
ISSN 0022-538X
Publication date 2007-07-01
Year available 2007
Sub-type Article (original research)
DOI 10.1128/JVI.00356-07
Open Access Status File (Publisher version)
Volume 81
Issue 13
Start page 7269
End page 7273
Total pages 5
Place of publication Washington, DC, United States
Publisher American Society of Microbiology
Language eng
Subject C1
320202 Cellular Immunology
730100 Clinical (Organs, Diseases and Abnormal Conditions)
Abstract Human cytomegalovirus (HCMV) elicits a very large burden on the immune system, with approximately one in ten T cells being reserved solely to manage this infection. However, information on the clonotypic composition of these vast T-cell populations is limited. In this study, we sequenced 116 T-cell receptor (TcR) alpha/beta-chains specific for the highly immunogenic HLA-B*3501-resticted epitope IPSINVHHY from the pp65 antigen. Interestingly, T cells recovered from all donors bore an identical or near-identical TRBV28/TRBJ14/TRAV17/TRAJ33 TcR. The ability to predict the responding alpha beta TcR repertoire before viral infection should prove a powerful tool for basic and clinical immunology.
Keyword Virology
Ctl Response
Lymphocyte Subpopulations
Structural Basis
Infection
Immunity
Peptide
Clones
Recognition
Repertoire
Diversity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Tue, 19 Feb 2008, 03:32:55 EST