Bidirectional synaptic plasticity at nociceptive afferents in the rat central amygdala

Lopez de Armentia, M. and Sah, P. (2007) Bidirectional synaptic plasticity at nociceptive afferents in the rat central amygdala. Journal of Physiology, 581 3: 961-970. doi:10.1113/jphysiol.2007.101822


Author Lopez de Armentia, M.
Sah, P.
Title Bidirectional synaptic plasticity at nociceptive afferents in the rat central amygdala
Journal name Journal of Physiology   Check publisher's open access policy
ISSN 0022-3751
Publication date 2007-01-01
Sub-type Article (original research)
DOI 10.1113/jphysiol.2007.101822
Volume 581
Issue 3
Start page 961
End page 970
Total pages 10
Editor Large, W. A.
Huxley, C.
Place of publication United Kingdom
Publisher Wiley-Blackwell Publishing Ltd
Collection year 2008
Language eng
Subject 320704 Cellular Nervous System
730104 Nervous system and disorders
C1
Abstract Glutamatergic inputs arising from the parabrachial nucleus to neurons in the lateral sector of the central amygdala were studied in vitro. Tetanic stimulation of these inputs led to LTP that did not require activation of NMDA receptors or a rise of postsynaptic calcium. LTP was accompanied by a reduction in the paired-pulse ratio, indicating that LTP results from an increase in transmitter release probability. Activation of adenylyl cyclase with forskolin potentiated these inputs with a similar reduction in paired-pulse facilitation and occluded LTP induction. LTP was inhibited by the protein kinase A blocker H89. Low-frequency stimulation led to LTD that required activation of postsynaptic NMDA receptors and a rise in postsynaptic calcium. There was no change in paired-pulse facilitation with LTD. LTD was blocked by protein phosphatase blockers calyculin and okadaic acid. We conclude that parabrachial inputs to the lateral sector of the central amygdala show presynaptic LTP that requires activation of a presynaptic protein kinase A via a calcium-dependent adenylyl cyclase while LTD at the same synapses is postsynaptic and requires a rise in postsynaptic calcium and activation of protein phosphatase.
Keyword Physiology
Long-term Potentiation
Nr2b-containing Nmda Receptors
Subunit Composition
Lateral Amygdala
Central Nucleus
Differential Roles
Arthritic Pain
Cyclic-amp
Depression
Synapses
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Tue, 19 Feb 2008, 03:27:54 EST