Antimalarial activity of sera from subjects taking HIV protease inhibitors

Redmond, AM, Skinner-Adams, T, Andrews, KT, Gardiner, DL, Ray, J, Kelly, M and McCarthy, JS (2007) Antimalarial activity of sera from subjects taking HIV protease inhibitors. Aids, 21 6: 763-765. doi:10.1097/QAD.0b013e328031f41a

Author Redmond, AM
Skinner-Adams, T
Andrews, KT
Gardiner, DL
Ray, J
Kelly, M
McCarthy, JS
Title Antimalarial activity of sera from subjects taking HIV protease inhibitors
Journal name Aids   Check publisher's open access policy
ISSN 0269-9370
Publication date 2007-01-01
Sub-type Article (original research)
DOI 10.1097/QAD.0b013e328031f41a
Volume 21
Issue 6
Start page 763
End page 765
Total pages 3
Editor Autran, B.
Levy, J.A.
Phair, J.P.
Coutinho, R.
Place of publication Philadelphia, U.S.A.
Publisher Lippincott Williams & Wilkins
Language eng
Subject C1
320405 Medical Parasitology
730101 Infectious diseases
Abstract Synergy between HIV and malaria is being increasingly recognized. We examined the antimalarial activity of sera from subjects receiving chloroquine, no drugs or HAART. Sera from subjects taking ritonavir-boosted saquinavir or lopinavir significantly inhibited parasite growth (median of 55 and 69% inhibition, respectively). These results indicate that patients on protease inhibitors may be afforded some protection from malaria. The clinical relevance of these observations will require confirmation in controlled studies in malaria-endemic regions.
Keyword Immunology
Infectious Diseases
Immunodeficiency-virus Type-1
Placental Malaria
Western Kenya
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2008 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 23 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 26 times in Scopus Article | Citations
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Created: Tue, 19 Feb 2008, 02:50:37 EST