Plasma membrane Ca2+-ATPase expression during colon cancer cell line differentiation

Aung, C. S., Kruger, W. A., Poronnik, P., Roberts-Thomson, S. J. and Monteith, G. R. (2007) Plasma membrane Ca2+-ATPase expression during colon cancer cell line differentiation. Biochemical And Biophysical Research Communications, 355 4: 932-936. doi:10.1016/j.bbrc.2007.02.050


Author Aung, C. S.
Kruger, W. A.
Poronnik, P.
Roberts-Thomson, S. J.
Monteith, G. R.
Title Plasma membrane Ca2+-ATPase expression during colon cancer cell line differentiation
Formatted title
Plasma membrane Ca2-ATPase expression during colon cancer cell line differentiation
Journal name Biochemical And Biophysical Research Communications   Check publisher's open access policy
ISSN 0006-291X
Publication date 2007-01-01
Year available 2007
Sub-type Article (original research)
DOI 10.1016/j.bbrc.2007.02.050
Open Access Status DOI
Volume 355
Issue 4
Start page 932
End page 936
Total pages 5
Editor W. Baumeister
Place of publication San Diego, C.A. U.S.A.
Publisher Academic Press
Language eng
Subject C1
270199 Biochemistry and Cell Biology not elsewhere classified
780105 Biological sciences
Abstract The differentiation of colon cancer cell lines is associated with changes in calcium homeostasis. Concomitantly there are changes in the expression of some calcium transporters and G-protein-coupled receptors, which are capable of altering cytosolic-free calcium levels. Recent studies associate alterations in calcium transporter expression with tumourigenesis, such as changes in specific isoforms of the plasma membrane calcium ATPase (PMCA) in breast cancer cell lines. In this study, we examined the expression of PMCA isoforms in the HT-29 colon cancer cell line using two methods of differentiation (sodium butyrate-mediated and spontaneous post-confluency induced differentiation). Our studies show that differentiation of HT-29 colon cancer cells is associated with the up-regulation of the PMCA isoform PMCA4 but no significant alteration in PMCA1 These results suggest that PMCA4 may be important and have a specific role in colon cells as well as being significant in colon cancer tumourigenesis. (c) 2007 Elsevier Inc. All rights reserved.
Keyword Biochemistry & Molecular Biology
Biophysics
calcium
cancer
colon cancer
PMCA
mRNA
transcription
protein
calcium ATPase
Calcium-sensing Receptor
Breast-cancer
Null Mutation
Up-regulation
Gene
Ca2+
Atpase
Carcinoma
Transport
Isoforms
Q-Index Code C1
Institutional Status UQ

 
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Created: Tue, 19 Feb 2008, 02:41:33 EST