Commissure formation in the mammalian forebrain

Lindwall, Charlotta, Fothergill, Thomas and Richards, Linda J. (2007) Commissure formation in the mammalian forebrain. Current Opinion In Neurobiology, 17 1: 3-14. doi:10.1016/j.conb.2007.01.008

Author Lindwall, Charlotta
Fothergill, Thomas
Richards, Linda J.
Title Commissure formation in the mammalian forebrain
Journal name Current Opinion In Neurobiology   Check publisher's open access policy
ISSN 0959-4388
Publication date 2007-02-01
Year available 2007
Sub-type Article (original research)
DOI 10.1016/j.conb.2007.01.008
Open Access Status
Volume 17
Issue 1
Start page 3
End page 14
Total pages 12
Editor Tessier-Lavigne, M.
Place of publication London
Publisher Elsevier Ltd
Language eng
Subject C1
320702 Central Nervous System
780105 Biological sciences
Abstract Commissural formation in the mammalian brain is highly organised and regulated both by the cell-autonomous expression of transcription factors, and by non-cell-autonomous mechanisms including the formation of midline glial structures and their expression of specific axon guidance molecules. These mechanisms channel axons into the correct path and enable the subsequent connection of specific brain areas to their appropriate targets. Several key findings have been made over the past two years, including the discovery of novel mechanisms of action that 'classical' guidance factors such as the Slits, Netrins, and their receptors have in axon guidance. Moreover, novel guidance factors such as members of the Writ family, and extracellular matrix components such as heparan sulphate proteoglycans, have been shown to be important for mammalian brain commissure formation. Additionally, there have been significant discoveries regarding the role of FGF signalling in the formation of midline glial structures. In this review, we discuss the most recent advances in the field that have contributed to our current understanding of commissural development in the telencephalon.
Keyword Neurosciences
Midline Axon Guidance
Vertebrate Nervous-system
Colorectal-cancer Dcc
Knock-out Mice
Neuronal Migration
Sonic Hedgehog
Corticoseptal Boundary
Q-Index Code C1
Grant ID NS44054
Institutional Status UQ

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Created: Tue, 19 Feb 2008, 02:32:15 EST