The effect of static magnetic fields of moderate intensity on the activity and gadolinium block of MscL of E-coli

Petrov, E. and Martinac, B. (2007) The effect of static magnetic fields of moderate intensity on the activity and gadolinium block of MscL of E-coli. Biophysical Journal: 2007 BPS Annual Meeting Abstracts, Supplement: 112A-112A.

Author Petrov, E.
Martinac, B.
Title The effect of static magnetic fields of moderate intensity on the activity and gadolinium block of MscL of E-coli
Journal name Biophysical Journal: 2007 BPS Annual Meeting Abstracts   Check publisher's open access policy
ISSN 0006-3495
Publication date 2007-01-01
Year available 2007
Sub-type Published abstract
Issue Supplement
Start page 112A
End page 112A
Total pages 1
Place of publication Bethesda, MA
Publisher Biophysical Society
Language eng
Abstract The magnetic field of the Earth has for long been known to influence the behaviour and orientation of a variety of living organisms. Experimental studies of the magnetic sense have however, been impaired by the lack of a plausible cellular and/or molecular mechanism providing meaningful explanation for detection of magnetic fields by these organisms. Recently, mechanosensitive (MS) ion channels have been implied to play a role in magnetoreception. In this study we have investigated the effect of static magnetic fields (SMFs) of moderate intensity on the activity and gadolinium block of MscL, the bacterial MS channel of large conductance, which has served as a model channel to study the basic physical principles of mechanosensory transduction in living cells. In addition to showing that direct application of the magnetic field decreased the activity of the MscL channel our study demonstrates for the first time that SMFs can reverse the effect of gadolinium, a well known blocker of MS channels. The results of our study are consistent with a notion that (i) the effects of SMFs on the MscL channels may result from changes in physical properties of the lipid bilayer due to diamagnetic anisotropy of phospholipid molecules and consequently (ii) cooperative superdiamagnetism of phospholipid molecules under influence of SMFs could cause displacement of Gd3+ ions from the membrane bilayer and thus remove the MscL channel block. Supported by the Australian Research Council.
Keyword Biophysics
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Poster Presentation no. 518-Pos

Document type: Journal Article
Sub-type: Published abstract
Collections: Journal Article Import (ISI/CVs)
Excellence in Research Australia (ERA) - Collection
 
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Created: Tue, 19 Feb 2008, 02:12:15 EST