Sry and the hesitant beginnings of male development

Polanco, Juan Carlos and Koopman, Peter (2007) Sry and the hesitant beginnings of male development. Developmental Biology, 302 1: 13-24. doi:10.1016/j.ydbio.2006.08.049


Author Polanco, Juan Carlos
Koopman, Peter
Title Sry and the hesitant beginnings of male development
Formatted title
Sry and the hesitant beginnings of male development
Journal name Developmental Biology   Check publisher's open access policy
ISSN 0012-1606
Publication date 2007-02-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.ydbio.2006.08.049
Volume 302
Issue 1
Start page 13
End page 24
Total pages 12
Place of publication San Diego
Publisher Elsevier Science
Collection year 2008
Language eng
Subject C1
270205 Genetic Development (incl. Sex Determination)
780105 Biological sciences
060403 Developmental Genetics (incl. Sex Determination)
Formatted abstract
In mammals, Sry (sex-determining region Y gene) is the master regulator of male sex determination. The discovery of Sry in 1990 was expected to provide the key to unravelling the network of gene regulation underlying testis development. Intriguingly, no target gene of SRY protein has yet been discovered, and the mechanisms by which it mediates its developmental functions are still elusive. What is clear is that instead of the robust gene one might expect as the pillar of male sexual development, Sry function hangs by a thin thread, a situation that has profound biological, medical and evolutionary implications. Copyright © 2006 Elsevier Inc. All rights reserved
Keyword Developmental Biology
Sry
sex determination
molecular mechanism
evolution
testis development
brain gender
Determining Gene Sry
Testis-determining Gene
Sex-determining Gene
Mobility-group Domain
Pre-sertoli Cells
Mouse Genital Ridge
Xx Transgenic Mice
Hmg Box Region
Campomelic Dysplasia
Nuclear Import
Q-Index Code C1
Q-Index Status Confirmed Code
Additional Notes This is a journal review

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 56 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 19 Feb 2008, 02:08:44 EST