The effect of the lipid layer on tear film behaviour

Jones, MB, McElwain, DLS, Fulford, GR, Collins, MJ and Roberts, AP (2006) The effect of the lipid layer on tear film behaviour. Bulletin of Mathematical Biology, 68 6: 1355-1381. doi:10.1007/s11538-006-9105-9

Author Jones, MB
McElwain, DLS
Fulford, GR
Collins, MJ
Roberts, AP
Title The effect of the lipid layer on tear film behaviour
Journal name Bulletin of Mathematical Biology   Check publisher's open access policy
ISSN 0092-8240
Publication date 2006-01-01
Year available 2006
Sub-type Article (original research)
DOI 10.1007/s11538-006-9105-9
Open Access Status
Volume 68
Issue 6
Start page 1355
End page 1381
Total pages 27
Place of publication New York
Publisher Springer
Language eng
Subject 2800 Neuroscience
2403 Immunology
2600 Mathematics
1300 Biochemistry, Genetics and Molecular Biology
2300 Environmental Science
3004 Pharmacology
1100 Agricultural and Biological Sciences
1703 Computational Theory and Mathematics
Abstract This paper investigates the effect of surfactants during tear film deposition and subsequent thinning. The surfactants occur naturally on the surface of the tear film in the form of a lipid layer. A lubrication model is developed that describes lipid spreading and film height evolution. It is shown that lipids may play an important role in drawing the tear film up the cornea during the opening phase of the blink. Further, nonuniform distributions of lipids may lead to a rapid thinning of the tear film behind the advancing lipid front (shock). Experiments using a fluorescein dye technique and using a tearscope were undertaken in order to visualise the motion of the lipid layer and any associated shocks immediately after a blink. It is found that the lipid layer continues to spread upwards on the cornea after the opening phase of the blink, in agreement with the model. Using the experimental data, lipid particles were tracked in order to determine the surface velocity and these results are compared to the model predictions.
Keyword Biology
Mathematical & Computational Biology
tear film
lipid layer
thin film
dry eye
Evaporation Rate
Oily Layer
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Physical Sciences Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 26 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 29 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sat, 26 Jan 2008, 02:55:46 EST