Influence of the frequency parameter on extracellular glutamate and gamma-aminobutyric acid in substantia nigra and globus pallidus during electrical stimulation of subthalamic nucleus in rats

Windels, F., Bruet, N., Poupard, A., Feuerstein, C., Bertrand, A. and Savasta, M. (2003) Influence of the frequency parameter on extracellular glutamate and gamma-aminobutyric acid in substantia nigra and globus pallidus during electrical stimulation of subthalamic nucleus in rats. Journal of Neuroscience Research, 72 2: 259-267. doi:10.1002/jnr.10577


Author Windels, F.
Bruet, N.
Poupard, A.
Feuerstein, C.
Bertrand, A.
Savasta, M.
Title Influence of the frequency parameter on extracellular glutamate and gamma-aminobutyric acid in substantia nigra and globus pallidus during electrical stimulation of subthalamic nucleus in rats
Journal name Journal of Neuroscience Research   Check publisher's open access policy
ISSN 0360-4012
Publication date 2003-04-01
Sub-type Article (original research)
DOI 10.1002/jnr.10577
Open Access Status
Volume 72
Issue 2
Start page 259
End page 267
Total pages 9
Place of publication New York
Publisher Wiley-liss
Language eng
Subject 11 Medical and Health Sciences
1101 Medical Biochemistry and Metabolomics
Abstract High-frequency stimulation (HFS) of the subthalamic nucleus (STN) proves to be an efficient treatment for alleviating motor symptoms in Parkinson's disease (PD). However, the mechanisms of HFS underlying these clinical effects remain unknown. Using intracerebral microdialysis, we previously reported that HFS induces, in normal rats, a significant increase of extracellular glutamate (Glu) in the globus pallidus (GP in rats or GPe in primates) and the substantia nigra pars reticulata (SNr), whereas gamma-aminobutyric acid (GABA) was increased only in the SNr. Bradykinesia can be improved by STN stimulation in a frequency-dependent manner, a plateau being reached around 130 Hz. The aim of the present study was to determine whether neurochemical changes are also frequency dependent. Electrical STN stimulation was applied at various frequencies (10, 60, 130, and 350 Hz) in normal rats. The results show that, for Glu, the amplitude of increase detected in GP and SNr is maximal at 130 Hz and is maintained at 350 Hz. No modifications of GABA were observed in GP whatever the frequency applied, whereas, in SNr, GABA increased from 60 to 350 Hz. Our results provide new neurochemical data implicating STN target structures in deep-brain-stimulation mechanisms. (C) 2003 Wiley-Liss, Inc.
Keyword Neurosciences
deep brain stimulation
subthalamic nucleus
globus pallidus
substantia nigra pars reticulata
intracerebral microdialysis
amino acids
high-performance liquid chromatography
Deep Brain-stimulation
Advanced Parkinsons-disease
Pars Reticulata
Basal Ganglia
Electrophysiological Data
Neuronal-activity
Nervous-system
Cell-bodies
Amino-acids
Dopamine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Queensland Brain Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 113 times in Thomson Reuters Web of Science Article | Citations
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Created: Sat, 26 Jan 2008, 01:54:25 EST