Lingford-Hughes, A, Davies, SJC, McIver, S, Williams, TM, Daglish, MRC and Nutt, DJ (2003) Addiction. British Medical Bulletin, 65 209-222. doi:10.1093/bmb/ldg65.209

Author Lingford-Hughes, A
Davies, SJC
McIver, S
Williams, TM
Daglish, MRC
Nutt, DJ
Title Addiction
Journal name British Medical Bulletin   Check publisher's open access policy
ISSN 0007-1420
Publication date 2003-01-01
Year available 2003
Sub-type Article (original research)
DOI 10.1093/bmb/ldg65.209
Open Access Status DOI
Volume 65
Start page 209
End page 222
Total pages 14
Place of publication Oxford
Publisher Oxford Univ Press
Language eng
Abstract Alcohol and psycho-active substance misuse has far-reaching social, psychological and physical consequences. Advances in neuroimaging technology have allowed neurobiological theories of addiction to become better characterized. We describe the neurobiology of dependence, withdrawal, abstinence and craving states in alcohol, stimulant and opiate misuse. Structural neuroimaging techniques such as CT and MRI with new analytical approaches such as voxel-based morphometry have shown wide-spread changes in stimulant and opiate abuse and atrophy, particularly in the frontal lobes, in alcoholism. Functional neuroimaging techniques such as PET, SPECT and fMRI reveal altered regional cerebral activity by all drugs of abuse. The neurochemistry of addiction, particularly involving dopamine, serotonin, opiate and GABA, has been studied with PET and SPECT and similarities between all drugs of abuse have been found such as reduced dopaminergic markers. The evidence derived from these advances in neuroimaging is likely to herald the emergence of new biological treatments in this important field.
Keyword Medicine, General & Internal
Cerebral Blood-flow
Gaba-benzodiazepine Receptor
Opiate-dependent Subjects
Brain Glucose-metabolism
Dopamine Transporter
Serotonin Transporter
Cocaine Dependence
Alcoholic Subjects
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 29 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 40 times in Scopus Article | Citations
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Created: Sat, 26 Jan 2008, 01:54:19 EST