Effects of restraint stress on responsiveness of atria and vas deferens in Sprague-Dawley rats

Singh, A, Einstein, R and Lavidis, N (2001) Effects of restraint stress on responsiveness of atria and vas deferens in Sprague-Dawley rats. Journal of Autonomic Pharmacology, 21 5-6: 255-261. doi:10.1046/j.1365-2680.2001.00234.x


Author Singh, A
Einstein, R
Lavidis, N
Title Effects of restraint stress on responsiveness of atria and vas deferens in Sprague-Dawley rats
Journal name Journal of Autonomic Pharmacology   Check publisher's open access policy
ISSN 0144-1795
Publication date 2001-01-01
Sub-type Article (original research)
DOI 10.1046/j.1365-2680.2001.00234.x
Volume 21
Issue 5-6
Start page 255
End page 261
Total pages 7
Place of publication Oxford
Publisher Blackwell Publishing Ltd
Language eng
Abstract 1 The effects of stress in rats were evaluated by measuring changes in body weight and in responsiveness to noradrenaline (NA) in the isolated vas deferens and atria after the animals had been exposed to restraint or restraint and isolation. 2 Animals which were subjected to restraint alone (1 h day(-1) for 3, 7 or 28 days) had a significantly reduced rate of body weight gain. This effect was not potentiated by the additional stress of isolation. 3 Restraint alone did not produce significant changes in the responsiveness of the vas deferens to NA. However, adding isolation to restraint, as an additional stress, produced a further leftward shift of the NA dose-response curve for the vas deferens, so that there was a significant increase in sensitivity compared with control. 4 There was a significant rightward shift in the NA dose-response curves or reduction in sensitivity in the atria from animals which had been restrained for 7 or 28 days. Isolation did not produce a further rightward shift in the NA dose-response curve. 5 The results from this study indicate that the stress associated with repeated restraint reduces the rate of weight gain and reduces the responsiveness of the atria to NA. The responsiveness of the vas deferens to NA was increased by stress, but the combined effect of isolation and restraint was required to produce a significant effect. The differences in the effects of stress on these tissues could be associated with differences in presynaptic receptor populations.
Keyword Neurosciences
Pharmacology & Pharmacy
vas deferens
atria
noradrenaline
restraint stress
isolation stress
Sprague-Dawley rats
Immobilization Stress
Blood-pressure
Food-intake
Responses
Adrenoceptors
Exposure
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
 
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Created: Sat, 26 Jan 2008, 01:41:40 EST