Novel cytotoxic compounds from the ascidian Lissoclinum bistratum

Degnan, B. M., Hawkins, C. J., Lavin, M. F., McCaffrey, E. J., Parry, D. L. and Watters, D. J. (1989) Novel cytotoxic compounds from the ascidian Lissoclinum bistratum. Journal of Medicinal Chemistry, 32 6: 1354-1359. doi:10.1021/jm00126a035

Author Degnan, B. M.
Hawkins, C. J.
Lavin, M. F.
McCaffrey, E. J.
Parry, D. L.
Watters, D. J.
Title Novel cytotoxic compounds from the ascidian Lissoclinum bistratum
Journal name Journal of Medicinal Chemistry   Check publisher's open access policy
ISSN 0022-2623
Publication date 1989-01-01
Sub-type Article (original research)
DOI 10.1021/jm00126a035
Volume 32
Issue 6
Start page 1354
End page 1359
Total pages 6
Place of publication Easton, Pa.
Publisher American Chemical Society
Language eng
Subject 270200 Genetics
Abstract The isolation and structures of two new cyclic hexapeptides and two new macrocyclic ethers from the aplousobranch ascidian Lissoclinum bistratum are described. Their structures were determined by two-dimensional NMR techniques. The hexapeptides, named bistratamide A and bistratamide B, differ only by the presence or absence of one double bond. They were tested for cytotoxicity toward human fibroblast and tumor cell lines and displayed similar toxicities to the octapeptides called patellamides from Lissoclinum patella. The peptides are found within the obligate algal symbiont Prochloron but clearly differ from peptides isolated from the same Prochloron of L. patella. The macrocyclic ethers isolated from L. bistratum are exceedingly potent in cytotoxicity. They have been named bistratenes A and B, and structures for these compounds are proposed.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Degnan Laboratory
School of Biological Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 112 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 06 Dec 2007, 02:40:06 EST by Laura McTaggart