The ets multigene family is conserved throughout the Metazoa

Degnan, B. M., Degnan, S. M., Naganuma, T. and Morse, D. E. (1993) The ets multigene family is conserved throughout the Metazoa. Nucleic Acids Research., 21 15: 3479-3484. doi:10.1093/nar/21.15.3479

Author Degnan, B. M.
Degnan, S. M.
Naganuma, T.
Morse, D. E.
Title The ets multigene family is conserved throughout the Metazoa
Journal name Nucleic Acids Research.   Check publisher's open access policy
ISSN 1362-4962
Publication date 1993-07-25
Year available 1993
Sub-type Article (original research)
DOI 10.1093/nar/21.15.3479
Open Access Status DOI
Volume 21
Issue 15
Start page 3479
End page 3484
Total pages 6
Place of publication Oxford
Publisher Oxford University Press
Language eng
Subject 270504 Invertebrate Biology
270200 Genetics
Abstract This study provides the first empirical evidence for the conservation of the ets proto-oncogene transcription factor family throughout the Metazoa. Using the polymerase chain reaction with degenerate primers corresponding to conserved sequences within the ETS DNA-binding domain, we have detected ets genes in a range of lower metazoans, including sponges, ctenophores, anemones, flatworms and nematodes, and in severai higher invertebrate metazoans. Many of these sequences are significantly divergent from the original v-eta-1 oncogene, although most can be aligned with recently defined groups within the ets gene family. Multiple ETS domain sequences were detected in a number of the lower metazoan species, providing evidence for the existence of an ets multigene family at the earliest stages of metazoan evolution. In contrast, we were unable to detect any ETS sequences in fungal, plant or several protozoan DNAs. Our findings suggest that the duplication and divergence of ets proto-oncogenes responsible for generating the multigene family occurred concomitantly with the development of metazoan animals. In addition, these data corroborate other recent molecular evidence in providing strong support for the monophyletic origin of all multicellular animals, including sponges.
Keyword Biochemistry & Molecular Biology
Biochemistry & Molecular Biology
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID R01-CA53105
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Degnan Laboratory
School of Biological Sciences Publications
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Created: Thu, 06 Dec 2007, 02:08:00 EST by Laura McTaggart