Block of voltage-gated calcium channels by peptide toxins

Schroeder, C. I., Lewis, R. J. and Adams, D. J. (2005). Block of voltage-gated calcium channels by peptide toxins. In Gerald W. Zamponi (Ed.), Voltage-Gated Calcium Channels (pp. 294-308) New York, U.S.A.: Springer US. doi:10.1007/0-387-27526-6_19


Author Schroeder, C. I.
Lewis, R. J.
Adams, D. J.
Title of chapter Block of voltage-gated calcium channels by peptide toxins
Title of book Voltage-Gated Calcium Channels
Place of Publication New York, U.S.A.
Publisher Springer US
Publication Year 2005
Sub-type Research book chapter (original research)
DOI 10.1007/0-387-27526-6_19
Year available 2005
Series Molecular Biology Intelligence Unit
ISBN 0-306-47840-4
9780306478406
978-0-387-27526-0
Editor Gerald W. Zamponi
Volume number XIV
Chapter number 19
Start page 294
End page 308
Total pages 15
Total chapters 23
Language eng
Subjects 270100 Biochemistry and Cell Biology
Abstract/Summary Peptide toxins that selectively block voltage sensitive calcium channels have contributed enormously to our understanding of the role of specific calcium channels in normal and pathological conditions. Several members of the ω-conotoxin class of calcium channel blockers are currently in clinical trials for chronic pain. While they are particularly efficacious when delivered intrathecally, side effects may limit their usage. Future advances will come with the discovery of new probes for VSCC subtypes, particularly those that are more selective for pain path-ways and disease states.
Keyword voltage-gated
calcium channels
peptide toxins
Q-Index Code B1

 
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Created: Wed, 24 Oct 2007, 15:09:07 EST by Belinda Weaver on behalf of Queensland Brain Institute