ATM and cellular response to DNA damage

Lavin, Martin F., Kozlov, Sergei, Gueven, Nuri, Peng, Cheng, Birrell, Geoff, Chen, Phillip and Scott, Shaun (2005). ATM and cellular response to DNA damage. In Erich A. Nigg (Ed.), Genome instability in cancer development (pp. 457-476) New York, USA: Springer.

Author Lavin, Martin F.
Kozlov, Sergei
Gueven, Nuri
Peng, Cheng
Birrell, Geoff
Chen, Phillip
Scott, Shaun
Title of chapter ATM and cellular response to DNA damage
Title of book Genome instability in cancer development
Place of Publication New York, USA
Publisher Springer
Publication Year 2005
Sub-type Research book chapter (original research)
Series Advances in Experimental Medicine and Biology: v. 570
ISBN 9781402037634
ISSN 0065-2598
Editor Erich A. Nigg
Volume number 570
Chapter number 4.2
Start page 457
End page 476
Total pages 20
Total chapters 4
Language eng
Subjects 11 Medical and Health Sciences
1112 Oncology and Carcinogenesis
Abstract/Summary Most human cancers display a myriad of genetic changes, a characteristic often attributed to genome instability. Cytogenetic studies have long identified chromosomal aberrations as a hallmark of human tumours, but the causes and consequences of genomic defects in tumours still remain to be fully understood. In particular, the role of genome instability in the development of human cancers as well as its relevance to treatment paradigms continue to evoke intense debate. To address these critical issues it is clearly important to understand the mechanisms that give rise to genome instability. This book reviews both genetic and biochemical data on the origin of genome instability and its impact on carcinogenesis. Reflecting recent discoveries and ongoing research, it discusses DNA repair mechanisms and hereditary cancer syndromes, as well as checkpoint mechanisms operating to safeguard chromosome integrity during cell cycle progression. Moreover, it summarises our current understanding of the various defects that may allow cancer cells to rapidly accumulate critical mutations and evolve, through processes reminiscent of Darwinian selection, an increasingly aggressive behaviour. Hopefully, this book will stimulate thought, discussion and experimentation, and serve as a rich source of information for a wide audience, including advanced students, researchers and clinical oncologists.
Keyword Medicine, Research & Experimental
Ataxia-telangiectasia cells
Double-strand breaks
Cycle checkpoint pathway
S-phase checkpoint
Mre11 complex
Retinoblastoma fibroblasts
Dependent phosphorylation
Missense mutations
Q-Index Code B1

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Created: Thu, 18 Oct 2007, 00:37:36 EST