Polymorphisms of genes coding for insulin-like growth factor I and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study

Canzian, F., McKay, J. D., Cleveland, R. J., Dossus, L., Biessy, C., Rinaldi, S., Landi, S., Boillot, C., Monnier, S., Chajes, V., Clavel-Chapelon, F., Tehard, B., Chang-Claude, J., Linseisen, J., Lahmann, P. H., Pischon, T., Trichopoulos, D., Trichopoulou, A., Zilis, D., Palli, D., Tumino, R., Vineis, P., Berrino, F., Bueno-de-Mesquita, H. B., van Gils, C. H., Peeters, P. H. M., Pera, G., Ardanaz, E., Chirlaque, M. D., Quiros, J. R., Larranaga, N., Martinez-Garcia, C., Allen, N. E., Key, T. J., Bingham, S. A., Khaw, K. T., Slimani, N., Norat, T., Riboli, E. and Kaaks, R. (2006) Polymorphisms of genes coding for insulin-like growth factor I and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study. British Journal of Cancer, 94 2: 299-307. doi:10.1038/sj.bjc.6602936


Author Canzian, F.
McKay, J. D.
Cleveland, R. J.
Dossus, L.
Biessy, C.
Rinaldi, S.
Landi, S.
Boillot, C.
Monnier, S.
Chajes, V.
Clavel-Chapelon, F.
Tehard, B.
Chang-Claude, J.
Linseisen, J.
Lahmann, P. H.
Pischon, T.
Trichopoulos, D.
Trichopoulou, A.
Zilis, D.
Palli, D.
Tumino, R.
Vineis, P.
Berrino, F.
Bueno-de-Mesquita, H. B.
van Gils, C. H.
Peeters, P. H. M.
Pera, G.
Ardanaz, E.
Chirlaque, M. D.
Quiros, J. R.
Larranaga, N.
Martinez-Garcia, C.
Allen, N. E.
Key, T. J.
Bingham, S. A.
Khaw, K. T.
Slimani, N.
Norat, T.
Riboli, E.
Kaaks, R.
Title Polymorphisms of genes coding for insulin-like growth factor I and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study
Journal name British Journal of Cancer   Check publisher's open access policy
ISSN 0007-0920
1532-1827
Publication date 2006-01-01
Sub-type Article (original research)
DOI 10.1038/sj.bjc.6602936
Open Access Status DOI
Volume 94
Issue 2
Start page 299
End page 307
Total pages 9
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Insulin-like growth factor I (IGF-1) stimulates cell proliferation and can enhance the development of tumours in different organs. Epidemiological studies have shown that an elevated level of circulating IGF-1 is associated with increased risk of breast cancer, as well as of other cancers. Most of circulating IGF-I is bound to an acid-labile subunit and to one of six insulin-like growth factor binding proteins (IGFBPs), among which the most important are IGFBP-3 and IGFBP-1. Polymorphisms of the IGF1 gene and of genes encoding for the major IGF-1 carriers may predict circulating levels of IGF-1 and have an impact on cancer risk. We tested this hypothesis with a case - control study of 807 breast cancer patients and 1588 matched control subjects, nested within the European Prospective Investigation into Cancer and Nutrition. We genotyped 23 common single nucleotide polymorphisms in IGF1, IGFBP1, IGFBP3 and IGFALS, and measured serum levels of IGF-1 and IGFBP-3 in samples of cases and controls. We found a weak but significant association of polymorphisms at the 50 end of the IGF1 gene with breast cancer risk, particularly among women younger than 55 years, and a strong association of polymorphisms located in the 50 end of IGFBP3 with circulating levels of IGFBP-3, which confirms previous findings. Common genetic variation in these candidate genes does not play a major role in altering breast cancer risk in Caucasians.
Keyword Oncology
IGF-I
IGFBP-3
IGFBP-1
IGFALS
single nucleotide polymorphisms
breast cancer
Prostate-cancer
Colorectal-cancer
Plasma-levels
Alpha-5-beta-1 Integrin
Premenopausal Women
Multiethnic Cohort
Factor (igf)-i
Genotype Data
Serum-levels
C-peptide
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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