LRP5 genetic variants influence bone mineral density in men

Koay, MA, Yeung, S, Brown, MA and Ebeling, PR (2005) LRP5 genetic variants influence bone mineral density in men. Journal of Bone And Mineral Research, 20 9: S158-S158. doi:10.1093/hmg/ddv143


Author Koay, MA
Yeung, S
Brown, MA
Ebeling, PR
Title LRP5 genetic variants influence bone mineral density in men
Journal name Journal of Bone And Mineral Research   Check publisher's open access policy
ISSN 0884-0431
Publication date 2005-01-01
Sub-type Published abstract
DOI 10.1093/hmg/ddv143
Open Access Status DOI
Volume 20
Issue 9
Start page S158
End page S158
Total pages 1
Place of publication Washington
Publisher Amer Soc Bone & Mineral Res
Language eng
Abstract Previous studies have identified 63 single-nucleotide polymorphisms (SNPs) associated with bone mineral density (BMD) in adults. These SNPs are thought to reflect variants that influence bone maintenance and/or loss in adults. It is unclear whether they affect the rate of bone acquisition during adolescence. Bone measurements and genetic data were available on 6397 individuals from the Avon Longitudinal Study of Parents and Children at up to five follow-up clinics. Linear mixed effects models with smoothing splines were used for longitudinal modelling of BMD and its components bone mineral content (BMC) and bone area (BA), from 9 to 17 years. Genotype data from the 63 adult BMD associated SNPs were investigated individually and as a genetic risk score in the longitudinal model. Each additional BMD lowering allele of the genetic risk score was associated with lower BMD at age 13 [per allele effect size, 0.002 g/cm(2) (SE = 0.0001, P = 1.24 × 10(-38))] and decreased BMD acquisition from 9 to 17 years (P = 9.17 × 10(-7)). This association was driven by changes in BMC rather than BA. The genetic risk score explained ∼2% of the variation in BMD at 9 and 17 years, a third of that explained in adults (6%). Genetic variants that putatively affect bone maintenance and/or loss in adults appear to have a small influence on the rate of bone acquisition through adolescence.
Keyword Endocrinology & Metabolism
Q-Index Code CX
Q-Index Status Provisional Code
Grant ID 102215
MC_PC_15018
102215/2/13/2
MC_UU_12013/4
MC_UU_12013/9
Institutional Status Unknown

Document type: Journal Article
Sub-type: Published abstract
Collections: Excellence in Research Australia (ERA) - Collection
UQ Diamantina Institute Publications
 
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Created: Thu, 18 Oct 2007, 00:12:06 EST