Oestrogen receptor status, pathological complete response and prognosis in patients receiving neoadjuvant chemotherapy for early breast cancer

Ring, A. E., Smith, I. E., Ashley, S., Fulford, L. G. and Lakhani, S. R. (2004) Oestrogen receptor status, pathological complete response and prognosis in patients receiving neoadjuvant chemotherapy for early breast cancer. British Journal of Cancer, 91 12: 2012-2017. doi:10.1038/sj.bjc.6602235


Author Ring, A. E.
Smith, I. E.
Ashley, S.
Fulford, L. G.
Lakhani, S. R.
Title Oestrogen receptor status, pathological complete response and prognosis in patients receiving neoadjuvant chemotherapy for early breast cancer
Journal name British Journal of Cancer   Check publisher's open access policy
ISSN 0007-0920
1532-1827
Publication date 2004-01-01
Sub-type Article (original research)
DOI 10.1038/sj.bjc.6602235
Open Access Status DOI
Volume 91
Issue 12
Start page 2012
End page 2017
Total pages 6
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract The aim of this study was to ascertain if oestrogen receptor ( ER) status predicts for pathological complete response (pCR) to neoadjuvant chemotherapy in operable breast cancer, and the effects of pCR on survival. Using a single-institution database, 435 patients were identified, who received neoadjuvant chemotherapy for operable breast cancer and were eligible for the analysis. Patients whose tumours were ER negative were more likely to achieve a pCR than patients who were ER positive (21.6 vs 8.1%, P<0.001). Owing to a strong correlation between ER status and grade, these variables were not shown to be independent predictors of pCR. Overall survival ( OS) was better in those patients who achieved a pCR compared to those who did not (5-year OS 91 vs 73%; P = 0.02). This was still the case when only patients with ER-negative tumours were examined ( 5-year OS 90 vs 52%, P = 0.005), but not in the subset of patients with ER-positive tumours ( 5-year OS 93 vs 79%; P = 0.3). Therefore, patients with ER-negative tumours were found to be more likely to achieve a pCR to neoadjuvant chemotherapy than those with ER-positive tumours, and pathological response did not have prognostic significance in patients with ER-positive tumours.
Keyword Oncology
Neoadjuvant chemotherapy
Oestrogen receptor
Pathological response
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 17 Oct 2007, 23:16:47 EST