Postnatal changes in TASK-1 and TREK-1 expression in rat brain stem and cerebellum

Kanjhan, Refik, Anselme, Amy, Noakes, Peter and Bellingham, Mark (2004) Postnatal changes in TASK-1 and TREK-1 expression in rat brain stem and cerebellum. Neuroreport, 15 8: 1321-1324. doi:10.1097/01.wnr.0000127462.15985.dc

Author Kanjhan, Refik
Anselme, Amy
Noakes, Peter
Bellingham, Mark
Title Postnatal changes in TASK-1 and TREK-1 expression in rat brain stem and cerebellum
Journal name Neuroreport   Check publisher's open access policy
ISSN 0959-4965
Publication date 2004-06-07
Year available 2004
Sub-type Article (original research)
DOI 10.1097/01.wnr.0000127462.15985.dc
Open Access Status
Volume 15
Issue 8
Start page 1321
End page 1324
Total pages 4
Place of publication Philadelphia
Publisher Lippincott Williams & Wilkins
Language eng
Subject 1109 Neurosciences
Abstract Developmental changes in expression of two-pore domain K+ channels, TASK-1 and TREK-1, were investigated in the juvenile (postnatal day 13; P13) and adult (P105) rat brain stem and cerebellum using immunohistochemistry. In the juvenile, extensive TASK-1-like immunoreactivity (TASK-1-LIR) was seen among glial cells in the white matter (e.g., radial glia), which showed marked reduction in the adult. In contrast,TASK-1-LIR in neurons including cerebellar Purkinje and granule cells, hypoglossal and facial motoneurons, and ventrolateral medulla neurons was increased in the adult. TASK-1-LIR in neuroglia surrounding peripheral axons of cranial nerves was persistent. TREK-1-LIR was similar between ages, although TREK-1-LIR was neuronal and present only in juvenile cerebellar external germinal layer. Present results suggest roles for TASK-1 and K+ homeostasis in neuro-glial interaction, neurogenesis, differentiation, migration, axon guidance, synaptogenesis and myelination.
Keyword Neurosciences
Bergmann glia
2P K+
Domain K+ Channels
Potassium Channel
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
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Created: Wed, 17 Oct 2007, 23:13:39 EST