Prefrontal-subcortical dissociations underlying inhibitory control revealed by event-related fMRI

Kelly, A. M. Clare, Hester, Robert, Murphy, Kevin, Javitt, Daniel C., Foxe, John J. and Garavan, Hugh (2004) Prefrontal-subcortical dissociations underlying inhibitory control revealed by event-related fMRI. European Journal of Neuroscience, 19 11: 3105-3112. doi:10.1111/j.0953-816X.2004.03429.x

Author Kelly, A. M. Clare
Hester, Robert
Murphy, Kevin
Javitt, Daniel C.
Foxe, John J.
Garavan, Hugh
Title Prefrontal-subcortical dissociations underlying inhibitory control revealed by event-related fMRI
Journal name European Journal of Neuroscience   Check publisher's open access policy
ISSN 0953-816X
Publication date 2004-06-01
Sub-type Article (original research)
DOI 10.1111/j.0953-816X.2004.03429.x
Open Access Status
Volume 19
Issue 11
Start page 3105
End page 3112
Total pages 8
Place of publication Oxford
Publisher Blackwell Publishing Ltd
Language eng
Subject 1109 Neurosciences
Abstract Using event-related fMRI, this study investigated the neural dynamics of response inhibition under fluctuating task demands. Fourteen participants performed a GO/NOGO task requiring inhibition of a prepotent motor response to NOGO events that occurred as part of either a Fast or Slow presentation stream of GO stimuli. We compared functional activations associated with correct withholds (Stops) required during the Fast presentation stream of stimuli to Stops required during the Slow presentation stream. A predominantly right hemispheric network was activated across conditions, consistent with previous studies. Furthermore, a functional dissociation of activations between conditions was observed. Slow Stops elicited additional activation in anterior dorsal and polar prefrontal cortex and left inferior parietal cortex. Fast Stops showed additional activation in a network that included right dorsolateral prefrontal cortex, insula and dorsal striatum. These results are discussed in terms of our understanding of the impact of preparation on the distributed network underlying response inhibition and the contribution of subcortical areas, such as the basal ganglia, to executive control processes.
Keyword Neurosciences
basal ganglia
executive functions
functional neuroimaging
prefrontal cortex
Response Selection
Basal Ganglia
Functional Mri
Executive Functions
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 128 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 139 times in Scopus Article | Citations
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Created: Wed, 17 Oct 2007, 22:54:35 EST